Wippold F J, Gado M H, Morris J C, Duchek J M, Grant E A
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
Radiology. 1991 Apr;179(1):215-9. doi: 10.1148/radiology.179.1.2006279.
Volumetric indexes of cerebral atrophy obtained by using computed tomography (CT) were measured longitudinally in patients with senile dementia of the Alzheimer type (SDAT) and in healthy elderly control subjects. Measurements were made three times over a 51-month period. Of the original 44 patients with SDAT, five were available for CT examination at the last time of assessment (51 months); in contrast, 41 of the original 58 control subjects were still available for study at 51 months. As a group, scans of SDAT subjects showed greater atrophy than those of control subjects in all volumetric indexes at each time of testing and demonstrated greater progression of atrophy during the study period. However, the overlap of indexes between the patients with SDAT and the control subjects indicates that CT data cannot be used alone to predict the presence or progression of dementia in individual cases.
采用计算机断层扫描（CT）测量阿尔茨海默型老年痴呆症（SDAT）患者及健康老年对照者脑萎缩的容积指标，并进行纵向观察。在51个月的时间里进行了三次测量。最初的44例SDAT患者中，有5例在最后一次评估（51个月）时可进行CT检查；相比之下，最初的58例对照者中有41例在51个月时仍可用于研究。作为一个整体，SDAT患者组在每次测试时的所有容积指标上均显示出比对照者更大的萎缩，并且在研究期间萎缩进展更大。然而，SDAT患者与对照者之间指标的重叠表明，CT数据不能单独用于预测个体病例中痴呆症的存在或进展。
