Department of Internal Medicine; Division of Internal and Cardiovascular Medicine, University of Perugia, Via E. Dal Pozzo, 06126 Perugia, Italy.
Thromb Haemost. 2010 Jan;103(1):56-61. doi: 10.1160/TH09-08-0562. Epub 2009 Nov 13.
The association between venous thromboembolism and arterial thrombosis has emerged as consistent clinical observation in the last few years. While several experimental, epidemiological and pharmacologic studies support this association, the initial pathophysiological mechanism linking these two clinical conditions remains to be established. This review discusses the pathophysiological bases and a number of experimental and clinical observations suggesting that the common link between venous thromboembolism and arterial thrombosis is represented by a dysfunctional endothelium.
近年来，静脉血栓栓塞症和动脉血栓形成之间的关联已成为一致的临床观察结果。虽然有几项实验、流行病学和药理学研究支持这种关联，但将这两种临床情况联系起来的初始病理生理机制仍有待确定。本文讨论了病理生理学基础以及一些实验和临床观察结果，这些结果表明，静脉血栓栓塞症和动脉血栓形成之间的共同联系是由功能失调的内皮细胞引起的。
