Turabelidze George, Lin Mei, Butler Cindy, Fick Frank, Russo Tony
Missouri Department of Health and Senior Services, Jefferson City, MO, USA.
Mo Med. 2009 Nov-Dec;106(6):420-4.
This is a case-control study of viral meningitis outbreak in Perry County, Missouri. All case-patients had viral meningitis per routine CSF analysis or PCR testing. Enterovirus VP1-specific RT-PCR and sequencing was performed on CSF. Univariate and multivariable logistic regression analysis was done to evaluate risk factors. The meningitis attack rate was 1/1,000 population. The main risk factor for meningitis was association with childcare. In patients with signs of meningitis, but normal routine CSF analysis, molecular testing of the CSF is helpful for conclusive diagnosis.
这是一项关于密苏里州佩里县病毒性脑膜炎暴发的病例对照研究。所有病例患者经常规脑脊液分析或PCR检测确诊为病毒性脑膜炎。对脑脊液进行了肠道病毒VP1特异性逆转录聚合酶链反应（RT-PCR）及测序。采用单因素和多因素逻辑回归分析评估危险因素。脑膜炎发病率为千分之一。脑膜炎的主要危险因素是与儿童保育相关。对于有脑膜炎体征但常规脑脊液分析正常的患者，脑脊液分子检测有助于明确诊断。
