Department of Psychology, University of Missouri-Kansas City, 5100 Rockhill Road, Kansas City, MO 64110, USA.
Neuropsychology. 2010 Jan;24(1):77-83. doi: 10.1037/a0015046.
Cognitive fatigue is a common, often debilitating symptom of multiple sclerosis (MS). Although MS patients frequently report that fatigue negatively affects cognitive functioning, most studies have found little evidence for a direct relationship between self-reported cognitive fatigue and traditional measures of neuropsychological functioning. The purpose of the present study was to examine the association between self-reported cognitive fatigue and a measure of response time variability (RTV). MS patients demonstrated significantly higher RTV than controls, and RTV was highly correlated with self-reported cognitive fatigue among relapsing-remitting and secondary progressive MS patients. Results highlight the need to implement newer methods to further elucidate the relationship between cognitive fatigue and neuropsychological functioning in MS.
认知疲劳是多发性硬化症（MS）的一种常见且常常使人虚弱的症状。尽管 MS 患者经常报告疲劳会对认知功能产生负面影响，但大多数研究几乎没有发现自我报告的认知疲劳与神经心理学功能的传统测量之间存在直接关系的证据。本研究的目的是检查自我报告的认知疲劳与反应时变异性（RTV）测量之间的关联。MS 患者的 RTV 明显高于对照组，并且 RTV 与复发缓解型和继发进展型 MS 患者的自我报告认知疲劳高度相关。研究结果强调需要采用新方法来进一步阐明 MS 中认知疲劳与神经心理学功能之间的关系。
