Department of Psychology, University of Massachusetts, Boston and Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Brockton, Massachusetts 02125-3393, USA.
Neuropsychology. 2010 Jan;24(1):121-9. doi: 10.1037/a0016981.
The authors examined the relationship between neuropsychological performance and MRI of the orbital frontal cortex (OFC) and diffusion tensor imaging (DTI) of the cingulum bundle (CB) within groups of patients with schizophrenia and healthy subjects. The authors analyzed data from subjects, who had participated in prior MRI, DTI, and neuropsychological studies (Nakamura et al., 2008; Nestor et al., 2008). In comparison to healthy subjects, patients showed the expected reductions across CB fractional anisotropy (white matter) and OFC gray matter volume as well as lower neuropsychological scores. In addition, in comparison to healthy subjects, patients showed a very different pattern of functional-anatomical correlates. For patients, CB white matter but not OFC gray matter correlated with various aspects of intelligence, including general abilities and working memory. For controls, OFC gray matter but not CB white matter correlated with scores on tests of intelligence and decision making. These results point to the potentially important role of CB white matter in the neuropsychological disturbance in schizophrenia.
作者在精神分裂症患者组和健康对照组中，研究了眶额皮质（OFC）的神经心理学表现与磁共振成像（MRI）、扣带束（CB）的弥散张量成像（DTI）之间的关系。作者分析了曾参与过先前 MRI、DTI 和神经心理学研究的受试者的数据（Nakamura 等人，2008 年；Nestor 等人，2008 年）。与健康受试者相比，患者的 CB 各向异性分数（白质）和 OFC 灰质体积均出现预期下降，且神经心理学评分也更低。此外，与健康受试者相比，患者表现出非常不同的功能-解剖相关模式。对于患者来说，CB 白质而不是 OFC 灰质与智力的各个方面相关，包括一般能力和工作记忆。对于对照组，OFC 灰质而不是 CB 白质与智力和决策测试的分数相关。这些结果表明 CB 白质在精神分裂症的神经心理障碍中可能具有重要作用。
