Department of Psychology, University of Massachusetts, Boston, MA 02125-3393, USA.
Brain Imaging Behav. 2013 Mar;7(1):68-76. doi: 10.1007/s11682-012-9193-0.
We examined variability in performance on widely-used neuropsychological Wechsler tests of intelligence and memory in a large sample of persons with chronic schizophrenia, a subset of whom had also undergone prior studies of magnetic resonance imaging (MRI) of the orbital frontal cortex (OFC) gray matter and diffusion tensor imaging (DTI) of the cingulum bundle (CB) and the uncinate fasiculus (UF) white matter. In comparison to controls, persons with schizophrenia showed lower scores across neuropsychological tests, with most pronounced drops in processing speed and immediate memory, in relation to oral reading. For patients, greater declines in intelligence and memory each correlated with reduced CB white matter fractional anisotropy and reduced OFC gray matter, respectively. However, only memory decline correlated with severity of negative symptoms. Taken together, these data raise the intriguing question as to whether communication and motivational deficits expressed in negative symptoms may contribute to the relationship of auditory memory decline and OFC volume observed in this patient sample.
我们在一大群慢性精神分裂症患者中研究了广泛使用的韦氏智力和记忆神经心理学测试的表现变异性，其中一部分患者还进行了眶额皮质（OFC）灰质的磁共振成像（MRI）和扣带束（CB）和钩束（UF）白质的弥散张量成像（DTI）的先前研究。与对照组相比，精神分裂症患者在神经心理学测试中的得分较低，与阅读速度相关的处理速度和即时记忆下降最为明显。对于患者来说，智力和记忆的下降与 CB 白质各向异性分数的降低和 OFC 灰质的减少分别相关。然而，只有记忆下降与阴性症状的严重程度相关。总之，这些数据提出了一个有趣的问题，即阴性症状中表现出的沟通和动机缺陷是否可能导致在该患者样本中观察到的听觉记忆下降和 OFC 体积之间的关系。
