Nestor Paul G, Kubicki Marek, Gurrera Ronald J, Niznikiewicz Margaret, Frumin Melissa, McCarley Robert W, Shenton Martha E
Clinical Neuroscience Division.
Neuropsychology. 2004 Oct;18(4):629-637. doi: 10.1037/0894-4105.18.4.629.
Patients with schizophrenia (n = 41) and healthy comparison participants (n = 46) completed neuropsychological measures of intelligence, memory, and executive function. A subset of each group also completed magnetic resonance diffusion tensor imaging (DTI) studies (fractional anisotropy and cross-sectional area) of the uncinate fasciculus (UF) and cingulate bundle (CB). Patients with schizophrenia showed reduced levels of functioning across all neuropsychological measures. In addition, selective neuropsychological-DTI relationships emerged. Among patients but not controls, lower levels of declarative-episodic verbal memory correlated with reduced left UF, whereas executive function errors related to performance monitoring correlated with reduced left CB. The data suggested abnormal DTI patterns linking declarative-episodic verbal memory deficits to the left UF and executive function deficits to the left CB among patients with schizophrenia.
精神分裂症患者（n = 41）和健康对照参与者（n = 46）完成了智力、记忆和执行功能的神经心理学测量。每组中的一个子集还完成了钩状束（UF）和扣带束（CB）的磁共振扩散张量成像（DTI）研究（分数各向异性和横截面积）。精神分裂症患者在所有神经心理学测量中均表现出功能水平降低。此外，还出现了选择性神经心理学与DTI的关系。在患者而非对照组中，陈述性情景言语记忆水平较低与左侧UF减少相关，而与绩效监测相关的执行功能错误与左侧CB减少相关。数据表明，在精神分裂症患者中，DTI模式异常将陈述性情景言语记忆缺陷与左侧UF联系起来，将执行功能缺陷与左侧CB联系起来。
