Howard Hughes Medical Institute, University of California, Berkeley, 94720, USA.
Mol Cell. 2009 Dec 25;36(6):924-31. doi: 10.1016/j.molcel.2009.12.011.
Historically, developmental-stage- and tissue-specific patterns of gene expression were assumed to be determined primarily by DNA regulatory sequences and their associated activators, while the general transcription machinery including core promoter recognition complexes, coactivators, and chromatin modifiers was held to be invariant. New evidence suggests that significant changes in these general transcription factors including TFIID, BAF, and Mediator may facilitate global changes in cell-type-specific transcription.
从历史上看，基因表达的发育阶段和组织特异性模式被认为主要由 DNA 调控序列及其相关激活子决定，而包括核心启动子识别复合物、共激活因子和染色质修饰因子在内的一般转录机制被认为是不变的。新的证据表明，这些一般转录因子（包括 TFIID、BAF 和 Mediator）的显著变化可能促进细胞类型特异性转录的全局变化。
