Institut des Sciences de la Vie, Unité de biochimie de la nutrition, Université catholique de Louvain, Croix du Sud 2/8, 1348 Louvain-la-Neuve, Belgium.
Environ Pollut. 2010 May;158(5):1570-5. doi: 10.1016/j.envpol.2009.12.012. Epub 2010 Jan 12.
A previous study has shown a simultaneous increase of vitamin A and PCBs in grey seal (Halichoerus grypus) milk at late lactation (Debier et al., 2004). Here we sought to understand this unexpected relationship by comparing the dynamics of vitamin A and PCBs in the different tissue compartments of transfer. Lactating grey seals and their pups were sampled longitudinally in Scotland during the 2006 breeding season. As blubber reserves decreased, concentrations of vitamin A and PCBs increased during lactation in the inner layer of maternal blubber. A concomitant rise was observed in milk and consequently in the serum of suckling pups. The similar dynamics of vitamin A and PCBs in milk and inner blubber suggest a common mechanism of mobilisation from maternal body stores and transfer into the milk. A panel data analysis highlighted a negative impact of PCBs in milk and pup serum on vitamin A status in pup serum.
先前的研究表明，在灰海豹（Halichoerus grypus）的晚期哺乳期，其乳汁中的维生素 A 和多氯联苯（PCBs）同时增加（Debier 等人，2004 年）。在这里，我们通过比较不同转移组织隔间中维生素 A 和 PCBs 的动态来试图理解这种意外的关系。在 2006 年繁殖季节期间，在苏格兰对哺乳期灰海豹及其幼崽进行了纵向采样。随着脂肪储备的减少，母海豹内层脂肪中的维生素 A 和 PCBs 的浓度在哺乳期增加。在乳汁中观察到相应的上升，因此在哺乳期幼崽的血清中也观察到上升。在乳汁和内层脂肪中维生素 A 和 PCBs 的相似动力学表明存在从母体体储存中动员和转移到乳汁中的共同机制。面板数据分析强调了乳汁和幼崽血清中 PCBs 对幼崽血清中维生素 A 状态的负面影响。
