Duke University Medical Center, Department of Internal Medicine, Durham, NC 27710, USA.
J Clin Virol. 2010 Mar;47(3):286-8. doi: 10.1016/j.jcv.2009.12.012. Epub 2010 Jan 12.
Little is known about the clinical presentation and course of novel H1N1 influenza in summer camps.
To describe the clinical course and evaluate the effect of influenza treatment in a summer camp population.
Two large influenza outbreaks occurred in university-based residential camps between May 21 and August 2, 2009. Through active daily surveillance, medical evaluation at symptom onset, and data collection during isolation, we describe the clinical course of a large outbreak of novel H1N1 influenza.
Influenza-like illness (ILI) was documented in 119 individuals. Influenza A was confirmed in 66 (79%) of 84 samples tested. Three early samples were identified as novel H1N1. ILI cases had an average age of 15.7 years and 52% were male. Sixty-three were treated with oseltamivir or zanamivir, which was initiated within 24h of diagnosis. Cough, myalgia and sore throat occurred in 69, 64 and 63% of cases, respectively. The highest temperature over the course of illness (T(max)) occurred within 48h after symptom onset in 87.5% of individuals. Average T(max) was 38.4 degrees C (range 36.1-40.2 degrees C). Among confirmed influenza cases, 69% defervesced by 72h and 95% defervesced by 96h. Defervescence at 72h was not different in the treated and untreated groups (p=0.12).
Novel H1N1 generally has a mild, self-limited course in healthy adolescent campers. Defervescence occurred within 72h and was unaffected by treatment.
关于新型 H1N1 流感在夏令营中的临床表现和病程知之甚少。
描述夏令营人群中新型 H1N1 流感的临床过程并评估流感治疗效果。
2009 年 5 月 21 日至 8 月 2 日，在两所大学的住宿夏令营中发生了两次大型流感暴发。通过日常主动监测、发病时的医学评估以及隔离期间的数据收集，我们描述了一次大型新型 H1N1 流感暴发的临床过程。
共记录了 119 例流感样疾病（ILI）。在 84 个送检样本中，有 66 个（79%）检测到甲型流感。有 3 个早期样本被鉴定为新型 H1N1。ILI 病例的平均年龄为 15.7 岁，52%为男性。63 人接受了奥司他韦或扎那米韦治疗，这些药物在确诊后 24 小时内开始使用。69%、64%和 63%的病例分别出现咳嗽、肌痛和咽痛。87.5%的个体在发病后 48 小时内出现病程中的最高体温（Tmax）。平均 Tmax 为 38.4°C（范围 36.1-40.2°C）。在确诊的流感病例中，69%的人在 72 小时内退热，95%的人在 96 小时内退热。治疗组和未治疗组在 72 小时退热时间上没有差异（p=0.12）。
新型 H1N1 流感在健康的青少年夏令营营员中通常具有轻度、自限性的病程。退热发生在 72 小时内，不受治疗影响。
