Dartmouth Medical School, 704 Vail HP7785, Hanover, NH 03755, USA.
Health Phys. 2010 Feb;98(2):327-38. doi: 10.1097/HP.0b013e3181a6de5d.
The development of in vivo EPR has made it feasible to perform tooth dosimetry measurements in situ, greatly expanding the potential for using this approach for immediate screening after radiation exposures. The ability of in vivo tooth dosimetry to provide estimates of absorbed dose has been established through a series of experiments using unirradiated volunteers with specifically irradiated molar teeth placed in situ within gaps in their dentition and in natural canine teeth of patients who have completed courses of radiation therapy for head and neck cancers. Multiple measurements in patients who have received radiation therapy demonstrate the expected heterogeneous dose distributions. Dose-response curves have been generated using both populations and, using the current methodology and instrument, the standard error of prediction based on single 4.5-min measurements is approximately 1.5 Gy for inserted molar teeth and between 2.0 and 2.5 Gy in the more irregularly shaped canine teeth. Averaging of independent measurements can reduce this error significantly to values near 1 Gy. Developments to reduce these errors are underway, focusing on geometric optimization of the resonators, detector positioning techniques, and optimal data averaging approaches. In summary, it seems plausible that the EPR dosimetry techniques will have an important role in retrospective dosimetry for exposures involving large numbers of individuals.
体内 EPR 的发展使得在体牙剂量测量成为可能，极大地扩展了这种方法在辐射暴露后的即时筛选中的应用潜力。通过一系列实验，使用未辐照的志愿者，将特定辐照的磨牙置于其牙列中的间隙内，并将天然犬齿置于已完成头颈部癌症放射治疗的患者的牙列中，体内牙剂量测量提供吸收剂量估计的能力已经得到了证实。对接受过放射治疗的患者进行的多次测量表明存在预期的不均匀剂量分布。已经使用这两个群体生成了剂量-反应曲线，并且，使用当前的方法和仪器，基于单次 4.5 分钟测量的预测标准误差对于插入的磨牙约为 1.5 Gy，而在形状不规则的犬齿中约为 2.0 至 2.5 Gy。独立测量的平均值可以将此误差显着降低到接近 1 Gy 的值。正在进行减少这些误差的开发工作，重点是谐振器的几何优化、探测器定位技术和最佳数据平均方法。总之，似乎可以合理地认为 EPR 剂量测定技术将在涉及大量个体的暴露后回溯剂量测定中发挥重要作用。
