Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Immunol Cell Biol. 2010 Mar-Apr;88(3):250-6. doi: 10.1038/icb.2009.115. Epub 2010 Jan 12.
Eosinophils, innate immune leukocytes elicited by Th2 cells, have long been associated with the effector arm of Th2 immune responses. However, accumulating data over the past decade reveal a much more dynamic picture of Th2 immunity, where eosinophils are present very early in response to Th2-inducing agents and function in the initiation of Th2 immunity. Here we discuss recent data showing immune functions of eosinophils distinct from their previously appreciated tissue- and helminth-destructive capacities, providing strong evidence for a new paradigm of Th2 immunity defined by a dynamic interplay between eosinophils and T cells.
嗜酸性粒细胞是由 Th2 细胞引发的先天免疫白细胞，长期以来一直与 Th2 免疫应答的效应臂有关。然而，过去十年中积累的数据揭示了 Th2 免疫更为动态的图景，在对 Th2 诱导剂的反应中，嗜酸性粒细胞很早就存在，并在 Th2 免疫的启动中发挥作用。在这里，我们讨论了最近的数据，这些数据显示了嗜酸性粒细胞的免疫功能与它们以前被认为的组织和寄生虫破坏性能力不同，为 Th2 免疫的一个新范式提供了强有力的证据，这个新范式的特点是嗜酸性粒细胞和 T 细胞之间的动态相互作用。
