Johns Hopkins University, Department of Biomedical Engineering, 3400 N. Charles St., Clark Hall, Baltimore, MD, USA.
Lab Chip. 2010 Jan 21;10(2):161-4. doi: 10.1039/b917503b. Epub 2009 Oct 9.
We demonstrate single biomolecule detection and quantification within sub-nanolitre droplets through application of Cylindrical Illumination Confocal Spectroscopy (CICS) and droplet confinement within a retractable microfluidic constriction.
我们通过应用圆柱形照明共焦光谱学(CICS)和在可缩回微流控收缩内限制液滴,在亚纳升级液滴内实现了单个生物分子的检测和定量。