关于在炎症性肠病诊断中使用血清学标志物的争议。
Controversies about the use of serological markers in diagnosis of inflammatory bowel disease.
出版信息
World J Gastroenterol. 2010 Jan 14;16(2):279-80. doi: 10.3748/wjg.v16.i2.279.
Abstract
The serological markers are increasingly used in diagnosis of inflammatory bowel disease (IBD). D-lactate and diamine oxidase are new indicators that can be used to reveal the damage to intestinal mucosa and permeability alteration in IBD. Although the two biological markers seem more sensitive, recent clinical trials and animal experiments have shown controversies about the use of them in diagnosis of IBD. Therefore, these markers should be interpreted cautiously and further prospective studies are needed to establish their clinical role in diagnosis of IBD.
摘要
血清学标志物在炎症性肠病（IBD）的诊断中应用越来越广泛。D-乳酸和二胺氧化酶是可用于揭示 IBD 中肠黏膜损伤和通透性改变的新指标。虽然这两种生物标志物似乎更敏感，但最近的临床试验和动物实验表明，在 IBD 的诊断中使用它们存在争议。因此，这些标志物的解读应谨慎，并需要进一步的前瞻性研究来确定它们在 IBD 诊断中的临床作用。
相似文献
1
Controversies about the use of serological markers in diagnosis of inflammatory bowel disease.关于在炎症性肠病诊断中使用血清学标志物的争议。
World J Gastroenterol. 2010 Jan 14;16(2):279-80. doi: 10.3748/wjg.v16.i2.279.
2
Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease.炎症性肠病患者的可溶性细胞间黏附分子-1、D-乳酸和二胺氧化酶
World J Gastroenterol. 2009 Aug 21;15(31):3916-9. doi: 10.3748/wjg.15.3916.
3
What is the role of serological markers in the diagnosis of IBD?血清学标志物在炎症性肠病的诊断中起什么作用？
Inflamm Bowel Dis. 2008 Oct;14 Suppl 2:S185-6. doi: 10.1002/ibd.20585.
4
Procalcitonin in inflammatory bowel disease: A diagnostic or prognostic marker.降钙素原在炎症性肠病中的作用：诊断或预后标志物。
Pathol Res Pract. 2024 Oct;262:155548. doi: 10.1016/j.prp.2024.155548. Epub 2024 Aug 15.
5
Evaluation of novel serological markers and autoantibodies in dogs with inflammatory bowel disease.评价新型血清学标志物和自身抗体在犬炎症性肠病中的作用。
J Vet Intern Med. 2020 May;34(3):1177-1186. doi: 10.1111/jvim.15761. Epub 2020 Apr 13.
6
Fecal calprotectin levels and serological responses to microbial antigens among children and adolescents with inflammatory bowel disease.炎症性肠病患儿及青少年的粪便钙卫蛋白水平及对微生物抗原的血清学反应
Inflamm Bowel Dis. 2009 Feb;15(2):199-205. doi: 10.1002/ibd.20535.
7
Utility of serological markers in inflammatory bowel diseases: gadget or magic?血清学标志物在炎症性肠病中的作用：小工具还是神奇之物？
World J Gastroenterol. 2007 Apr 14;13(14):2028-36. doi: 10.3748/wjg.v13.i14.2028.
8
Comparison of serological markers of inflammatory bowel disease with clinical diagnosis in children.儿童炎症性肠病血清学标志物与临床诊断的比较
Inflamm Bowel Dis. 2004 May;10(3):240-4. doi: 10.1097/00054725-200405000-00010.
9
Serological markers in inflammatory bowel diseases.炎症性肠病中的血清学标志物。
Best Pract Res Clin Gastroenterol. 2003 Feb;17(1):19-35. doi: 10.1053/bega.2002.0347.
10
Evolution of Pediatric Inflammatory Bowel Disease Unclassified (IBD-U): Incorporated With Serological and Gene Expression Profiles.小儿炎症性肠病未分类（IBD-U）的演变：与血清学和基因表达谱相结合。
Inflamm Bowel Dis. 2018 Sep 15;24(10):2285-2290. doi: 10.1093/ibd/izy136.
引用本文的文献
1
Yinlai Decoction Protects Microstructure of Colon and Regulates Serum Level of D-Lactic Acid in Pneumonia Mice Fed with High-Calorie and High-Protein Diet.银莱方对高热量高蛋白饮食肺炎小鼠结肠组织形态及血清 D-乳酸水平的影响
Chin J Integr Med. 2023 Aug;29(8):714-720. doi: 10.1007/s11655-023-3697-x. Epub 2023 Jun 21.
2
What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract.我们对胃肠道中芳香族和阳离子生物胺的已知与未知
Foods. 2018 Sep 4;7(9):145. doi: 10.3390/foods7090145.
本文引用的文献
1
Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease.炎症性肠病患者的可溶性细胞间黏附分子-1、D-乳酸和二胺氧化酶
World J Gastroenterol. 2009 Aug 21;15(31):3916-9. doi: 10.3748/wjg.15.3916.
2
Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals.分析灵敏度的提高揭示了健康个体中二胺氧化酶活性存在与性别相关的变异性。
Clin Biochem. 2007 Nov;40(16-17):1339-41. doi: 10.1016/j.clinbiochem.2007.07.019. Epub 2007 Aug 11.
3
D-lactic acid metabolism after an oral load of DL-lactate.口服DL-乳酸负荷后的D-乳酸代谢
Clin Nutr. 1990 Feb;9(1):23-8. doi: 10.1016/0261-5614(90)90069-5.
4
Intestinal permeability and genetic determinants in patients, first-degree relatives, and controls in a high-incidence area of Crohn's disease in Southern Italy.意大利南部克罗恩病高发地区患者、一级亲属及对照人群的肠道通透性与遗传决定因素
Am J Gastroenterol. 2005 Dec;100(12):2730-6. doi: 10.1111/j.1572-0241.2005.00325.x.
5
Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?克罗恩病家族中肠道通透性增加的遗传基础：CARD15 3020insC突变的作用？
Gut. 2006 Mar;55(3):342-7. doi: 10.1136/gut.2005.065557. Epub 2005 Jul 6.
6
Identification of putative mammalian D-lactate dehydrogenase enzymes.推定的哺乳动物D-乳酸脱氢酶的鉴定。
Biochem Biophys Res Commun. 2002 Jul 26;295(4):910-6. doi: 10.1016/s0006-291x(02)00768-4.
7
D-Lactate transport and metabolism in rat liver mitochondria.大鼠肝脏线粒体中D-乳酸的转运与代谢
Biochem J. 2002 Jul 15;365(Pt 2):391-403. doi: 10.1042/BJ20020139.
8
Is an increased intestinal permeability a valid predictor of relapse in Crohn disease?肠道通透性增加是克罗恩病复发的有效预测指标吗？
Scand J Gastroenterol. 2001 May;36(5):521-7.
9
Metabolic utilization and renal handling of D-lactate in men.男性体内D-乳酸的代谢利用及肾脏处理
Metabolism. 1985 Jul;34(7):621-5. doi: 10.1016/0026-0495(85)90088-5.
10
Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor.克罗恩病患者及其亲属肠道通透性增加。一个可能的病因因素。
Ann Intern Med. 1986 Dec;105(6):883-5. doi: 10.7326/0003-4819-105-6-883.
Zotero 插件