World J Gastroenterol. 2010 Jan 14;16(2):279-80. doi: 10.3748/wjg.v16.i2.279.
The serological markers are increasingly used in diagnosis of inflammatory bowel disease (IBD). D-lactate and diamine oxidase are new indicators that can be used to reveal the damage to intestinal mucosa and permeability alteration in IBD. Although the two biological markers seem more sensitive, recent clinical trials and animal experiments have shown controversies about the use of them in diagnosis of IBD. Therefore, these markers should be interpreted cautiously and further prospective studies are needed to establish their clinical role in diagnosis of IBD.
血清学标志物在炎症性肠病（IBD）的诊断中应用越来越广泛。D-乳酸和二胺氧化酶是可用于揭示 IBD 中肠黏膜损伤和通透性改变的新指标。虽然这两种生物标志物似乎更敏感，但最近的临床试验和动物实验表明，在 IBD 的诊断中使用它们存在争议。因此，这些标志物的解读应谨慎，并需要进一步的前瞻性研究来确定它们在 IBD 诊断中的临床作用。
