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Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis.植物甾醇古古甾酮通过阻断IκB激酶抑制肠上皮细胞中的核因子-κB信号传导，并改善急性小鼠结肠炎。
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Gastroenterology. 1999 Apr;116(4):874-83. doi: 10.1016/s0016-5085(99)70070-3.
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Serum D-lactate levels as a predictor of intestinal ischemia-reperfusion injury.血清D-乳酸水平作为肠道缺血再灌注损伤的预测指标。
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炎症性肠病患者的可溶性细胞间黏附分子-1、D-乳酸和二胺氧化酶

Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease.

作者信息

Song Wei-Bing, Lv Yong-Hui, Zhang Zhen-Shu, Li Ya-Nan, Xiao Li-Ping, Yu Xin-Pei, Wang Yuan-Yuan, Ji Hong-Li, Ma Li

机构信息

Department of Gerontology, Guangzhou General Hospital of PLA, Guangzhou 510010, Guangdong Province, China.

出版信息

World J Gastroenterol. 2009 Aug 21;15(31):3916-9. doi: 10.3748/wjg.15.3916.

DOI:10.3748/wjg.15.3916
PMID:19701972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2731254/
Abstract

AIM

To study the levels of serum soluble intercellular adhesion molecule-1 (sICAM-1), plasma D-lactate and diamine oxidase (DAO) in patients with inflammatory bowel disease (IBD), and the potential clinical significance.

METHODS

Sixty-nine patients with IBD and 30 healthy controls were included in this study. The concentration of sICAM-1 was detected with enzyme-linked immunosorbent assay, the level of D-lactate and DAO was measured by spectroscopic analysis, and the number of white blood cells (WBC) was determined by routine procedure.

RESULTS

The levels of sICAM-l, DAO, and WBC in IBD patients were significantly higher than those in the control group (P < 0.01). sICAM-l in IBD patients was found to be closely related to the levels of DAO and D-lactate (212.94 +/- 69.89 vs 6.35 +/- 2.35, P = 0.000), DAO 212.94 +/- 69.89 vs 8.65 +/- 3.54, P = 0.000) and WBC (212.94 +/- 69.89 vs 7.40 +/- 2.61, P = 0.000), but no significant difference was observed between patients with ulcerative colitis and patients with Crohn's disease. The post-treatment levels of sICAM-l, D-lactate and WBC were significantly lower than before treatment (sICAM-l 206.57 +/- 79.21 vs 146.21 +/- 64.43, P = 0.000), (D-lactate 1.46 +/- 0.94 vs 0.52 +/- 0.32, P = 0.000) and (WBC 7.24 +/- 0.2.33 vs 5.21 +/- 3.21, P = 0.000).

CONCLUSION

sICAM-1, D-lactate and DAO are closely related to the specific conditions of IBD, and thus could be used as a major diagnostic index.

摘要

目的

研究炎症性肠病（IBD）患者血清可溶性细胞间黏附分子-1（sICAM-1）、血浆D-乳酸和二胺氧化酶（DAO）水平及其潜在的临床意义。

方法

本研究纳入69例IBD患者和30例健康对照者。采用酶联免疫吸附测定法检测sICAM-1浓度，用光谱分析法测定D-乳酸和DAO水平，通过常规程序测定白细胞（WBC）数量。

结果

IBD患者的sICAM-1、DAO和WBC水平显著高于对照组（P<0.01）。发现IBD患者的sICAM-1与DAO和D-乳酸水平密切相关（212.94±69.89对6.35±2.35，P = 0.000），DAO（212.94±69.89对8.65±3.54，P = 0.000）和WBC（212.94±69.89对 7.40±2.61，P = 0.000），但溃疡性结肠炎患者和克罗恩病患者之间未观察到显著差异。治疗后sICAM-1、D-乳酸和WBC水平显著低于治疗前（sICAM-1 206.57±79.21对146.21±64.43，P = 0.000），（D-乳酸1.46±0.94对0.52±0.32，P = 0.000）和（WBC 7.24±2.33对5.21±3.21，P = 0.000）。

结论

sICAM-1、D-乳酸和DAO与IBD的具体病情密切相关，因此可作为主要诊断指标。