Frierson H F
Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908.
Am J Surg Pathol. 1991 Apr;15(4):358-67. doi: 10.1097/00000478-199104000-00004.
The results of flow cytometric analysis of ploidy and S-phase fraction for invasive breast cancers have been compared with various clinical and pathologic parameters by many investigators. Ploidy usually has been found to be associated with histologic type, tumor grade, and S-phase fraction values, but not with patient age, menopausal status, tumor size, axillary nodal status, estrogen receptor status, or progesterone receptor status. S-phase fraction values have correlated with histologic type, grade, estrogen receptor status, and progesterone receptor status, but not with menopausal status or axillary nodal status. Although in several studies ploidy and S-phase fraction have been compared with patient outcome, only a few of these reports have stratified data according to the histologic types and grades of the neoplasms. There is conflicting information regarding the value of ploidy analysis for women with either node-negative or node-positive breast carcinoma. Data from a few studies seem to indicate that S-phase fraction alone or in combination with ploidy may be more important prognostically than ploidy alone, although the results have not been uniform. More studies that examine ploidy, S-phase fraction, various important clinical and pathologic variables, and outcome for patients with invasive mammary cancer must be performed before the clinical importance of DNA analysis by flow cytometry becomes known.
许多研究者已将浸润性乳腺癌的倍体和S期细胞分数的流式细胞术分析结果与各种临床和病理参数进行了比较。通常发现倍体与组织学类型、肿瘤分级和S期细胞分数值相关，但与患者年龄、绝经状态、肿瘤大小、腋窝淋巴结状态、雌激素受体状态或孕激素受体状态无关。S期细胞分数值与组织学类型、分级、雌激素受体状态和孕激素受体状态相关，但与绝经状态或腋窝淋巴结状态无关。尽管在一些研究中已将倍体和S期细胞分数与患者预后进行了比较，但这些报告中只有少数根据肿瘤的组织学类型和分级对数据进行了分层。关于倍体分析对淋巴结阴性或阳性乳腺癌女性的价值，存在相互矛盾的信息。一些研究的数据似乎表明，单独的S期细胞分数或与倍体结合在预后方面可能比单独的倍体更重要，尽管结果并不一致。在通过流式细胞术进行DNA分析的临床重要性为人所知之前，必须开展更多研究，以检查浸润性乳腺癌患者的倍体、S期细胞分数、各种重要的临床和病理变量以及预后情况。
