Sachs M K
Division of Infectious Diseases, Jefferson Medical College, Philadelphia, Pa 19107.
Arch Dermatol. 1991 Apr;127(4):493-6.
Cellulitis has long been postulated to be the result of antecedent bacterial invasion with subsequent bacterial proliferation. Nonetheless, the difficulty in isolating putative pathogens from cellulitic skin has served to cast doubt on this hypothesis. In this regard, the skin is provided with a unique set of lymphoid and reticular cells with the capacity to secrete lymphokines and cytokines. These substances rapidly reduce the number of viable bacteria from infection by enhancing the infiltration of skin by circulating macrophages and neutrophils. The warmth and erythema associated with cellulitis are most likely produced both by a small number of residual bacteria and by fragmented bacterial remnants, and amplified by the lymphokines that are secreted in response to antigenic challenge. Anti-inflammatory agents may play a significant role in enhancing the resolution of infection by reducing the production of soluble mediators by these intra-epidermal immunocompetent cells.
长期以来，蜂窝织炎一直被认为是先前细菌入侵并随后细菌增殖的结果。然而，从蜂窝织炎皮肤中分离出假定病原体的困难对这一假说提出了质疑。在这方面，皮肤具有一组独特的淋巴和网状细胞，能够分泌淋巴因子和细胞因子。这些物质通过增强循环巨噬细胞和中性粒细胞对皮肤的浸润，迅速减少感染中活细菌的数量。与蜂窝织炎相关的发热和红斑很可能是由少量残留细菌和破碎的细菌残骸共同产生的，并由抗原刺激后分泌的淋巴因子放大。抗炎药物可能通过减少这些表皮内免疫活性细胞产生可溶性介质，在促进感染消退方面发挥重要作用。
