North Carolina State University, NC, USA.
Int J Geriatr Psychiatry. 2010 Jul;25(7):748-55. doi: 10.1002/gps.2417.
To examine the frequency of Mild Cognitive Impairment (MCI) in African American older adults. The study also plans to explore the specific cognitive domains of impairment as well as whether there are differences in demographics, health, and cognitive performance between MCI and normal participants.
Cross-sectional.
Independent-living sample of urban dwelling elders in Baltimore, Maryland.
The sample consisted of 554 subjects ranging in age from 50 to 95 (Mean = 68.79 +/- 9.60).
Socio-demographics and health were assessed. Several cognitive measures were administered to assess inductive reasoning, declarative memory, perceptual speed, working memory, executive functioning, language and global cognitive functioning.
Approximately 22% of participants were considered MCI (i.e. 18% non-amnestic vs. 4% amnestic). A majority of the non-amnestic MCI participants had impairment in one cognitive domain, particularly language and executive function. Individuals classified as non-amnestic MCI were significantly older and had more years of education than normal individuals. The MCI groups were not significantly different than cognitively normal individuals on health factors. Individuals classified as MCI performed significantly worse on global cognitive measures as well as across specific cognitive domains than cognitively normal individuals.
This study demonstrates that impairment in a non-memory domain may be an early indicator of cognitive impairment, particularly among African Americans.
调查非裔美国老年人轻度认知障碍(MCI)的发生率。本研究还计划探讨具体的认知受损领域,以及 MCI 患者与正常参与者在人口统计学、健康和认知表现方面是否存在差异。
横断面研究。
马里兰州巴尔的摩市独立居住的城市老年人样本。
该样本由 554 名年龄在 50 至 95 岁之间的受试者组成(平均年龄为 68.79 ± 9.60)。
评估社会人口统计学和健康状况。采用多种认知测试评估归纳推理、陈述性记忆、知觉速度、工作记忆、执行功能、语言和整体认知功能。
约 22%的参与者被认为患有 MCI(即 18%非遗忘型与 4%遗忘型)。大多数非遗忘型 MCI 患者在一个认知领域存在障碍,特别是语言和执行功能。被归类为非遗忘型 MCI 的个体明显比正常个体年龄更大,受教育程度更高。MCI 组与认知正常个体在健康因素方面没有显著差异。与认知正常个体相比,被归类为 MCI 的个体在整体认知测试以及特定认知领域的表现明显更差。
本研究表明,非记忆领域的损伤可能是非裔美国人认知障碍的早期指标。