单纯疱疹病毒与小鼠淋巴细胞的相互作用。I. 单纯疱疹病毒的促有丝分裂特性。
The interaction of Herpes Simplex Virus with murine lymphocytes. I. Mitogenic properties of herpes simplex virus.
作者信息
Mochizuki D, Hedrick S, Watson J, Kingsbury D T
出版信息
J Exp Med. 1977 Dec 1;146(6):1500-10. doi: 10.1084/jem.146.6.1500.
Abstract
Herpes simplex virus (HSV) stimulates DNA synthesis in mouse spleen cultures prepared from normal, macrophage-depleted, and T-cell-depleted spleen cells, but not from thymocytes. In addition, a polyclonal antibody response is observed in HSV-infected spleen cultures. These findings indicate that the cells stimulated to undergo DNA synthesis after HSV infection appear to be the bone marrow-derived lymphocytes. The newly synthesized DNA is host cell and not of viral origin. Heat treatment and ultraviolet irradiation of HSV before addition to spleen cultures prevents the induction of DNA synthesis. We consider the use of this system as assay for the study of cell transformation by HSV and also for the study of host cell control of the expression of the viral genome.
摘要
单纯疱疹病毒（HSV）可刺激由正常、巨噬细胞耗竭和T细胞耗竭的脾细胞制备的小鼠脾细胞培养物中的DNA合成，但不能刺激胸腺细胞中的DNA合成。此外，在HSV感染的脾细胞培养物中观察到多克隆抗体反应。这些发现表明，HSV感染后被刺激进行DNA合成的细胞似乎是骨髓来源的淋巴细胞。新合成的DNA是宿主细胞的，而非病毒来源的。在将HSV添加到脾细胞培养物之前进行热处理和紫外线照射可阻止DNA合成的诱导。我们认为该系统可用于研究HSV诱导的细胞转化以及宿主细胞对病毒基因组表达的控制。
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