从转化缺陷型突变体诱导的肿瘤中恢复禽肉瘤病毒。
Recovery of avian sarcoma virus from tumors induced by transformation-defective mutants.
作者信息
Hanafusa H, Halpern C C, Buchhagen D L, Kawai S
出版信息
J Exp Med. 1977 Dec 1;146(6):1735-47. doi: 10.1084/jem.146.6.1735.
Abstract
Transformation-defective (td) mutants of the Schmidt-Ruppin strain of Rous sarcoma virus (RSV), which contains deletions in the gene responsible for transformation (src gene), are unable to transform chicken embryo fibroblasts in vitro. Injection of some of these td mutants into newborn chickens resulted in the formation of sarcomas from which sarcoma virus was unfailingly recovered. The possibility that transforming RSV was present in the td virus preparations was excluded by further purification of the td viruses. Morphology of the foci induced by the newly recovered sarcoma virus was distinct from that of foci induced by the parental Schmidt Ruppin strain of RSV. It is suggested that the new sarcoma virus was generated as a result of the genetic interaction between the genomes of td virus and chicken cells.
摘要
劳氏肉瘤病毒（RSV）施密特-鲁平株的转化缺陷（td）突变体在负责转化的基因（src基因）中存在缺失，无法在体外转化鸡胚成纤维细胞。将其中一些td突变体注射到新生鸡体内会导致肉瘤形成，并且总能从中回收肉瘤病毒。通过进一步纯化td病毒排除了td病毒制剂中存在转化型RSV的可能性。新回收的肉瘤病毒诱导形成的病灶形态与亲本施密特-鲁平株RSV诱导形成的病灶形态不同。有人认为，新的肉瘤病毒是td病毒基因组与鸡细胞基因组之间遗传相互作用的结果。
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