人类癌基因家族的染色体定位
Chromosomal assignment of a family of human oncogenes.
作者信息
Ryan J, Barker P E, Shimizu K, Wigler M, Ruddle F H
出版信息
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4460-3. doi: 10.1073/pnas.80.14.4460.
A family of human transforming genes, previously shown to share homology with the ras family of viral oncogenes, maps to three different human chromosomes. A well-characterized mouse-human hybrid cell panel, combined with Southern blotting, was used in this study. The transforming gene of the T24 bladder carcinoma cell line maps to human chromosome 11. An oncogene isolated from the lung carcinoma cell line SK-Calu-1 maps to human chromosome 12. The third ras-related gene, cloned from SK-N-SH, a neuroblastoma cell line, maps to human chromosome 1.
先前已表明与病毒致癌基因的ras家族具有同源性的一个人类转化基因家族，定位于三条不同的人类染色体上。本研究使用了一个特征明确的小鼠-人类杂交细胞系组合，结合Southern印迹法。T24膀胱癌细胞系的转化基因定位于人类11号染色体。从肺癌细胞系SK-Calu-1分离出的一个致癌基因定位于人类12号染色体。从神经母细胞瘤细胞系SK-N-SH克隆出的第三个ras相关基因定位于人类1号染色体。
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