HIV/AIDS Program, Prevention Division, Public Health-Seattle and King County, Seattle, Washington, USA.
J Natl Med Assoc. 2009 Dec;101(12):1205-13. doi: 10.1016/s0027-9684(15)31131-7.
Nephropathy complicates the course and adversely impacts on the prognosis of HIV-infected patients. We examined trends and correlates of all-cause nephropathy (ACN).
Correlates of and trends in ACN were examined in the entire Adult/Adolescent Spectrum of HIV Disease longitudinal observational cohort. Patients were enrolled and followed in the cohort for a median period of 3 years between January 1990 and December 2003 in 11 US metropolitan areas.
The incidence of ACN rose among HIV-infected individuals through the mid-1990s, then declined. The proportion of patients with ACN at the time of death increased over the study period. Black race, injection-drug use (IDU), indinavir, hypertension, diabetes, decreased CD4+ lymphocyte count, increased viral load, and increased age were all highly associated with ACN.
Nephropathy represents an important health disparity impacting HIV-infected blacks and IDU with implications for mortality.
肾病会影响 HIV 感染者的病程和预后。我们研究了全因肾病（ACN）的趋势和相关因素。
在整个成人/青少年艾滋病发病谱纵向观察队列中，我们研究了 ACN 的相关因素和趋势。该队列中的患者于 1990 年 1 月至 2003 年 12 月期间在 11 个美国大都市地区被纳入并随访，中位随访时间为 3 年。
ACN 在 HIV 感染者中的发病率在 20 世纪 90 年代中期上升，然后下降。在研究期间，死亡时患有 ACN 的患者比例增加。黑种人、注射吸毒（IDU）、茚地那韦、高血压、糖尿病、CD4+淋巴细胞计数下降、病毒载量增加和年龄增加均与 ACN 高度相关。
肾病是影响 HIV 感染的黑人和 IDU 的一个重要健康差异，对死亡率有影响。
