Bacteriology Laboratory, Brabois Hospital, University Hospital of Nancy, 54111 Vandoeuvre-les-Nancy, France.
Diagn Microbiol Infect Dis. 2010 Apr;66(4):366-72. doi: 10.1016/j.diagmicrobio.2009.11.002. Epub 2010 Jan 13.
The diagnosis of tuberculosis (TB) is difficult in children. The pediatricians are waiting for new and rapid tests that are easy to realize and that are performed better than tuberculin skin test (TST). We presented here the evaluation of QuantiFERON-TB Gold In-Tube (QFT-G IT) in the Children Hospital of Nancy. Fifty-one children were divided into 3 groups: healthy contacts (HC, n = 31), latent TB infection (LTBI, n = 13), and active TB (n = 7). QFT-G IT was positive in 0%, 15%, and 43% of children compared with 3%, 70%, and 57% for TST, respectively, for the HC, LTBI, and active TB groups. Indeterminate QFT-G IT occurred in 14% of the cases, seemed to correlate with young age, and was not explained by preanalytic parameters. In conclusion, despite its objectivity and its higher specificity (especially in Bacille Calmette-Guérin vaccinated children), the real place of QFT-G IT in TB diagnosis in children remains difficult to define.
结核病（TB）的诊断在儿童中较为困难。儿科医生正在等待新的、快速的检测方法，这些方法易于实现，并且比结核菌素皮肤试验（TST）更有效。我们在此介绍了在南锡儿童医院对 QuantiFERON-TB Gold In-Tube（QFT-G IT）的评估。51 名儿童分为 3 组：健康接触者（HC，n=31）、潜伏性结核感染（LTBI，n=13）和活动性 TB（n=7）。与 TST 相比，QFT-G IT 在 HC、LTBI 和活动性 TB 组中的阳性率分别为 0%、15%和 43%，而 TST 分别为 3%、70%和 57%。QFT-G IT 结果不确定的发生率为 14%，似乎与年龄较小有关，且不能用分析前参数来解释。总之，尽管 QFT-G IT 具有客观性和更高的特异性（尤其是在接种卡介苗的儿童中），但其在儿童结核病诊断中的实际地位仍难以确定。
