Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland.
Curr Opin Chem Biol. 2010 Apr;14(2):184-99. doi: 10.1016/j.cbpa.2009.11.026. Epub 2010 Jan 12.
In recent years, several complementary strategies have been implemented for the creation and optimization of artificial metalloenzymes. Selected examples outline the pros and cons of five different approaches: catalytic antibodies, computational design, directed evolution, artificial metal-cofactors and DNAzymes.
近年来，人们已经实施了几种互补策略来创造和优化人工金属酶。选择的例子概述了五种不同方法的优缺点：催化抗体、计算设计、定向进化、人工金属辅因子和 DNA 酶。
