人工氧活化金属酶的设计与工程
Design and engineering of artificial oxygen-activating metalloenzymes.
作者信息
Nastri Flavia, Chino Marco, Maglio Ornella, Bhagi-Damodaran Ambika, Lu Yi, Lombardi Angela
机构信息
Department of Chemical Sciences, University of Naples "Federico II", Via Cintia, 80126 Naples, Italy.
出版信息
Chem Soc Rev. 2016 Sep 21;45(18):5020-54. doi: 10.1039/c5cs00923e. Epub 2016 Jun 24.
Abstract
Many efforts are being made in the design and engineering of metalloenzymes with catalytic properties fulfilling the needs of practical applications. Progress in this field has recently been accelerated by advances in computational, molecular and structural biology. This review article focuses on the recent examples of oxygen-activating metalloenzymes, developed through the strategies of de novo design, miniaturization processes and protein redesign. Considerable progress in these diverse design approaches has produced many metal-containing biocatalysts able to adopt the functions of native enzymes or even novel functions beyond those found in Nature.
摘要
人们正在做出许多努力，设计和构建具有满足实际应用需求催化特性的金属酶。计算生物学、分子生物学和结构生物学的进展最近加速了该领域的发展。这篇综述文章重点介绍了通过从头设计、小型化过程和蛋白质重新设计策略开发的氧活化金属酶的最新实例。这些不同设计方法取得的显著进展已产生了许多含金属生物催化剂，它们能够具备天然酶的功能，甚至具有自然界中未发现的新功能。
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