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Neuroimmunomodulation. 2008;15(2):102-7. doi: 10.1159/000148192. Epub 2008 Aug 5.
2
Commentary: adopting [corrected] a broad perspective on posttraumatic stress disorders, childhood medical illness and injury.评论：对创伤后应激障碍、儿童期疾病与损伤采取广泛视角[已修正]。
J Pediatr Psychol. 2009 Jan-Feb;34(1):22-6. doi: 10.1093/jpepsy/jsn042. Epub 2008 Apr 25.
3
Symptoms of posttraumatic stress in parents of children with cancer: are they elevated relative to parents of healthy children?癌症患儿父母的创伤后应激症状：与健康儿童的父母相比，其症状是否更严重？
J Pediatr Psychol. 2009 Jan-Feb;34(1):4-13. doi: 10.1093/jpepsy/jsm119. Epub 2007 Dec 11.
4
Brief report: pediatric cancer, parental coping style, and risk for depressive, posttraumatic stress, and anxiety symptoms.简短报告：儿童癌症、父母应对方式以及抑郁、创伤后应激和焦虑症状的风险
J Pediatr Psychol. 2007 Nov-Dec;32(10):1272-7. doi: 10.1093/jpepsy/jsm057. Epub 2007 Aug 2.
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Acute stress in parents of children newly diagnosed with cancer.新诊断出患癌儿童的父母所面临的急性压力。
Pediatr Blood Cancer. 2008 Feb;50(2):289-92. doi: 10.1002/pbc.21262.
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Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder.去甲肾上腺素能功能障碍与创伤后应激障碍的精神药理学
Depress Anxiety. 2008;25(3):260-71. doi: 10.1002/da.20292.
7
Brief report: the risk of posttraumatic stress disorder in mothers of children diagnosed with pediatric cancer and type I diabetes.简短报告：被诊断患有儿童癌症和I型糖尿病的患儿母亲患创伤后应激障碍的风险
J Pediatr Psychol. 2007 Mar;32(2):223-9. doi: 10.1093/jpepsy/jsj120. Epub 2006 Apr 26.
8
Patterns of posttraumatic stress symptoms in parents of childhood cancer survivors.儿童癌症幸存者父母的创伤后应激症状模式。
J Fam Psychol. 2005 Sep;19(3):430-40. doi: 10.1037/0893-3200.19.3.430.
9
An integrative model of pediatric medical traumatic stress.儿童医学创伤应激的综合模型。
J Pediatr Psychol. 2006 May;31(4):343-55. doi: 10.1093/jpepsy/jsj054. Epub 2005 Aug 10.
10
Risk of posttraumatic stress symptoms: a comparison of child survivors of pediatric cancer and parental bereavement.创伤后应激症状的风险：儿科癌症儿童幸存者与父母丧亲儿童的比较。
J Pediatr Psychol. 2006 May;31(4):367-76. doi: 10.1093/jpepsy/jsj055. Epub 2005 Aug 10.

简要报告：皮质醇在儿童癌症诊断后母亲创伤后应激症状中的作用。

Brief report: Role of cortisol in posttraumatic stress symptoms among mothers of children diagnosed with cancer.

机构信息

Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, USA.

出版信息

J Pediatr Psychol. 2010 Oct;35(9):960-5. doi: 10.1093/jpepsy/jsp139. Epub 2010 Jan 12.

DOI:10.1093/jpepsy/jsp139
PMID:20071349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2948829/
Abstract

OBJECTIVE

To examine the role of cortisol in posttraumatic stress symptomatology among mothers of children newly diagnosed with cancer.

METHODS

Mothers (N = 27) completed standardized measures of posttraumatic stress symptoms and provided salivary cortisol samples at the time of their child's cancer diagnosis and then monthly for 1 year.

RESULTS

Random effects regression analyses of 351 person-by-time observations revealed that high levels of cortisol were associated with higher levels of posttraumatic stress symptoms (B = .12, p < .02). The mothers who exhibited higher cortisol levels at the time of their child's diagnosis showed statistically significant declines in symptomatology from diagnosis to 12 months postdiagnosis (B = .97, p < .0001) compared to mothers who exhibited lower cortisol levels at diagnosis (B = .003, p < .05).

CONCLUSIONS

These findings offer some suggestions into possible neurobiological processes underlying posttraumatic stress symptoms and directions for future research and clinical intervention.

摘要

目的

探讨皮质醇在儿童新诊断癌症母亲创伤后应激症状中的作用。

方法

母亲（N=27）在孩子癌症诊断时以及随后的 1 年内每月完成创伤后应激症状的标准化测量和唾液皮质醇样本采集。

结果

对 351 个个体-时间观察的随机效应回归分析显示，较高的皮质醇水平与较高的创伤后应激症状水平相关（B=0.12，p<.02）。与诊断时皮质醇水平较低的母亲相比，在孩子诊断时皮质醇水平较高的母亲，从诊断到诊断后 12 个月，症状学表现有显著下降（B=0.97，p<.0001）（B=0.003，p<.05）。

结论

这些发现为创伤后应激症状的可能神经生物学过程提供了一些启示，并为未来的研究和临床干预指明了方向。