Neu Madalynn, Matthews Ellyn, King Nancy A, Cook Paul F, Laudenslager Mark L
1University of Colorado Anschutz Medical Campus, Aurora CO, USA.
J Pediatr Oncol Nurs. 2014 Mar-Apr;31(2):104-13. doi: 10.1177/1043454213520346.
The purpose of this study was to compare anxiety, depression, and stress between mothers of children during maintenance treatment for acute lymphoblastic leukemia (ALL) and matched controls. Twenty-six mothers were recruited from the hematology unit at a children's hospital, and 26 mothers were recruited from the community. Participants were matched to their child's age and gender. Mothers completed the Hospital Anxiety and Depression Scale, the Perceived Stress Sale, and collected salivary cortisol 4 times a day for 3 consecutive days. Compared with mothers of healthy children, anxiety scores did not differ (P=.10), but depression scores were higher (P=.003) in mothers of children with ALL. More mothers in the ALL group scored above the cutoff of 7 indicating clinical anxiety (46%) and depressive symptoms (27%). A trend toward increased stress was found in mothers in the ALL group. No difference was found in overall daily cortisol (area under the curve), daily decrease in cortisol (slope), and cortisol awakening response. Mothers of children with ALL experienced emotional symptoms many months after the initial diagnosis.
本研究的目的是比较急性淋巴细胞白血病（ALL）维持治疗期间患儿母亲与匹配对照组母亲的焦虑、抑郁和压力状况。从一家儿童医院的血液科招募了26位母亲，从社区招募了26位母亲。参与者根据其孩子的年龄和性别进行匹配。母亲们完成了医院焦虑抑郁量表、感知压力量表，并连续3天每天4次采集唾液皮质醇。与健康儿童的母亲相比，ALL患儿母亲的焦虑评分无差异（P = 0.10），但抑郁评分更高（P = 0.003）。ALL组中更多母亲的得分高于表明临床焦虑（46%）和抑郁症状（27%）的临界值7分。ALL组母亲中发现有压力增加的趋势。在总体每日皮质醇（曲线下面积）、皮质醇每日下降幅度（斜率）和皮质醇觉醒反应方面未发现差异。ALL患儿的母亲在初次诊断后的数月内经历了情绪症状。
