Safaee A, Moghimi-Dehkordi B, Pourhoseingholi M A, Vahedi M, Maserat E, Ghiasi S, Fatemi S R, Zali M R
Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University (M.C.), Tehran, Iran.
Indian J Cancer. 2010 Jan-Mar;47(1):27-30. doi: 10.4103/0019-509X.58855.
In around 10 to 15% of all colorectal cancer (CRC) cases, a positive family history of colorectal cancer is observed . Although increased risk of colorectal cancer in individuals with a family history of the disease has been observed consistently in the past studies, limited information is available on colorectal cancer associated with family history in Iran.
The purpose of this study is to define the risk of colorectal cancer associated with a family history of cancer.
The present study was designed as an unmatched case control study. The cases were 393 patients with histologically confirmed colorectal carcinomas and there were 393 controls, randomly selected from among the healthy participants in a health survey.
The family history was extracted from a standard history form completed by the patient or from the record created by a health care provider.
Mantel-Heanszel Odds Ratio was computed for removing the confounding effect of age and sex.
A positive family history of cancer was reported by 36.4 and 24.4% among the cases and controls, respectively. Colorectal cancer risk increased two-fold in subjects who reported having first degree relatives with cancer. The adjusted odds ratio was 4.76, indicating that having a positive family history of colorectal cancer among relatives increased one's risk of colorectal cancer about 4.5-fold.
According to our findings, a family history of cancer increased the risk of CRC. Due to this fact that there is no current colorectal cancer screening program in Iran, it is recommended that first degree relatives of patients with colorectal cancer should be considered as a priority group for screening programs.
在所有结直肠癌（CRC）病例中，约10%至15%有结直肠癌家族史。尽管过去的研究一致观察到有该疾病家族史的个体患结直肠癌的风险增加，但关于伊朗与家族史相关的结直肠癌的信息有限。
本研究的目的是确定与癌症家族史相关的结直肠癌风险。
本研究设计为非匹配病例对照研究。病例为393例经组织学确诊的结直肠癌患者，对照组为393例，从健康调查中的健康参与者中随机选取。
家族史从患者填写的标准病史表格或医疗服务提供者创建的记录中提取。
计算Mantel - Heanszel优势比以消除年龄和性别的混杂效应。
病例组和对照组中分别有36.4%和24.4%报告有癌症家族史。报告有患癌一级亲属的受试者患结直肠癌的风险增加两倍。调整后的优势比为4.76，表明亲属中有结直肠癌家族史会使患结直肠癌的风险增加约4.5倍。
根据我们的研究结果，癌症家族史会增加患结直肠癌的风险。由于伊朗目前没有结直肠癌筛查项目，建议将结直肠癌患者的一级亲属视为筛查项目的优先群体。
