蛋白质修饰作为乳腺癌潜在的生物标志物
Protein modifications as potential biomarkers in breast cancer.
作者信息
Jin Hongjun, Zangar Richard C
机构信息
Cell Biology and Biochemistry Group, Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, PO Box 999, 902 Battelle Blvd, Richland, WA 99352.
出版信息
Biomark Insights. 2009 Nov 30;4:191-200. doi: 10.4137/bmi.s2557.
Abstract
A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying changes in PTMs. In this review, we summarize the current literature on PTMs identified in the plasma and tumor tissue of breast-cancer patients or in breast cell lines. We also discuss some of the analytical techniques currently being used to evaluate PTMs.
摘要
已知多种翻译后蛋白质修饰（PTM）会因癌症发展而发生改变。因此，这些PTM有可能成为乳腺癌的有用生物标志物。质谱分析、抗体微阵列和免疫组织化学技术在识别PTM变化方面已显示出前景。在本综述中，我们总结了目前关于在乳腺癌患者的血浆和肿瘤组织或乳腺细胞系中鉴定出的PTM的文献。我们还讨论了目前用于评估PTM的一些分析技术。
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