Dohi K, Iwano M, Muraguchi A, Horii Y, Hirayama T, Ogawa S, Shiiki H, Hirano T, Kishimoto T, Ishikawa H
First Department of Internal Medicine, Nara Medical University, Japan.
Clin Nephrol. 1991 Jan;35(1):1-5.
Our previous study has shown that interleukin 6 (IL-6), a multifunctional cytokine, is closely associated with the pathogenesis of mesangial proliferative glomerulonephritis (mesPGN). To investigate whether urinary IL-6 can be used as an indicator in the prognosis of patients with IgA nephropathy, we monitored IL-6 activity in the urine of patients with IgA nephropathy for 10 months and compared IL-6 activity with clinical data as well as the histological changes of the kidneys obtained from the patients. It was found that among the patients who had continuously high urinary IL-6 activity, histological progression of IgA nephropathy was observed. On the other hand, among the patients whose urinary IL-6 became undetectable during the 10-month follow-up, histological improvement of IgA nephropathy was observed. These data suggest that the measurement of urinary IL-6 is a helpful tool for monitoring the progression of IgA nephropathy.
我们之前的研究表明，多功能细胞因子白细胞介素6（IL-6）与系膜增生性肾小球肾炎（mesPGN）的发病机制密切相关。为了研究尿IL-6是否可作为IgA肾病患者预后的指标，我们对IgA肾病患者的尿液进行了10个月的IL-6活性监测，并将IL-6活性与临床数据以及患者肾脏的组织学变化进行了比较。结果发现，在尿IL-6活性持续较高的患者中，观察到了IgA肾病的组织学进展。另一方面，在10个月随访期间尿IL-6检测不到的患者中，观察到了IgA肾病的组织学改善。这些数据表明，检测尿IL-6是监测IgA肾病进展的有用工具。
