Rationale for interleukin-6 blockade in systemic lupus erythematosus.
作者信息
Tackey E, Lipsky P E, Illei G G
机构信息
Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, USA.
出版信息
Lupus. 2004;13(5):339-43. doi: 10.1191/0961203304lu1023oa.
Abstract
Interleukin-6 (IL-6) is a pleiotropic cytokine with a wide range of biological activities that plays an important role in immune regulation and inflammation. Among other actions, it induces terminal differentiation of B lymphocytes into antibody-forming cells and the differentiation of T cells into effector cells. IL-6 also has multiple potent proinflammatory effects. An association between IL-6 and lupus was demonstrated in murine models of SLE and blocking IL-6 improved lupus in all models tested. Data from several studies suggest that IL-6 plays a critical role in the B cell hyperactivity and immunopathology of human SLE, and may have a direct role in mediating tissue damage. Based on these data, we propose that blocking the effect of IL-6 in humans may improve lupus by interacting with the autoinflammatory process both systemically and locally.
摘要
相似文献
1
Rationale for interleukin-6 blockade in systemic lupus erythematosus.
Lupus. 2004;13(5):339-43. doi: 10.1191/0961203304lu1023oa.
2
Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus.抗白细胞介素-6单克隆抗体在系统性红斑狼疮小鼠模型中抑制自身免疫反应。
Immunology. 2006 Nov;119(3):296-305. doi: 10.1111/j.1365-2567.2006.02433.x.
3
Tumour necrosis factor and other proinflammatory cytokines in systemic lupus erythematosus: a rationale for therapeutic intervention.肿瘤坏死因子及其他促炎细胞因子在系统性红斑狼疮中的作用：治疗干预的理论依据
Lupus. 2004;13(5):344-7. doi: 10.1191/0961203303lu1024oa.
4
The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus.白细胞介素-6和白细胞介素-10在系统性红斑狼疮B细胞功能亢进中的作用
Inflamm Res. 1999 May;48(5):255-61. doi: 10.1007/s000110050456.
5
[Cytokine blockade - a promising therapeutic option in SLE].[细胞因子阻断——系统性红斑狼疮中一种有前景的治疗选择]
Z Rheumatol. 2008 Jul;67(4):315-7. doi: 10.1007/s00393-008-0303-8.
6
Interleukin-10 (IL-10) secretion in systemic lupus erythematosus and rheumatoid arthritis: IL-10-dependent CD4+CD45RO+ T cell-B cell antibody synthesis.系统性红斑狼疮和类风湿性关节炎中白细胞介素-10（IL-10）的分泌：IL-10依赖的CD4 + CD45RO + T细胞 - B细胞抗体合成
J Clin Immunol. 1996 Jul;16(4):198-207. doi: 10.1007/BF01541225.
7
Arthritis in systemic lupus erythematosus is characterized by local IL-17A and IL-6 expression in synovial fluid.系统性红斑狼疮关节炎的特征是滑液中局部表达的白细胞介素-17A 和白细胞介素-6。
Clin Exp Immunol. 2021 Jul;205(1):44-52. doi: 10.1111/cei.13585. Epub 2021 Mar 16.
8
Elevated IL-15 levels in systemic lupus erythematosus: potential pathogenesis insight and therapeutic target.系统性红斑狼疮患者白细胞介素 15 水平升高：潜在发病机制的洞察和治疗靶点。
Int Immunopharmacol. 2024 Dec 5;142(Pt A):112973. doi: 10.1016/j.intimp.2024.112973. Epub 2024 Aug 31.
9
IL-33 neutralization suppresses lupus disease in lupus-prone mice.白细胞介素-33中和作用可抑制狼疮易感小鼠的狼疮疾病。
Inflammation. 2014 Jun;37(3):824-32. doi: 10.1007/s10753-013-9802-0.
10
Impact of anti-interleukin-6 receptor blockade on circulating T and B cell subsets in patients with systemic lupus erythematosus.抗白细胞介素-6 受体阻断剂对系统性红斑狼疮患者循环 T 和 B 细胞亚群的影响。
Ann Rheum Dis. 2013 Jan;72(1):118-28. doi: 10.1136/annrheumdis-2012-201310. Epub 2012 Aug 2.
引用本文的文献
1
Low-dose rituximab in lupus enteritis: a comparative study on its efficacy in modulating mucosal immunity and reducing inflammation.低剂量利妥昔单抗治疗狼疮性肠炎：关于其调节黏膜免疫和减轻炎症疗效的比较研究
Arthritis Res Ther. 2025 Sep 29;27(1):183. doi: 10.1186/s13075-025-03653-1.
2
Interleukin-6 targeting antibodies for the treatment of Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD): A review of current literature.用于治疗髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）的白细胞介素-6靶向抗体：当前文献综述
AIMS Neurosci. 2025 May 8;12(2):113-139. doi: 10.3934/Neuroscience.2025008. eCollection 2025.
3
Gut Expansion of a Human Lupus Pathobiont is Associated With Autoantibody Production and T Cell Dysregulation.人类狼疮致病共生菌的肠道扩张与自身抗体产生及T细胞失调有关。
ACR Open Rheumatol. 2025 May;7(5):e70033. doi: 10.1002/acr2.70033.
4
Correlation of periodontitis with hepatic and intestinal inflammation and glycemic control, and effects of bioconverted by SMFM2016-RK.牙周炎与肝脏和肠道炎症及血糖控制的相关性，以及SMFM2016-RK生物转化的影响。
J Oral Microbiol. 2025 Mar 14;17(1):2473246. doi: 10.1080/20002297.2025.2473246. eCollection 2025.
5
Flame retardant, hexabromocyclododecane, increases production of pro-inflammatory cytokines, interleukin 1-beta and interleukin 6, in human immune cells.阻燃剂六溴环十二烷可增加人类免疫细胞中促炎细胞因子白细胞介素1-β和白细胞介素6的产生。
J Appl Toxicol. 2025 Feb;45(2):273-287. doi: 10.1002/jat.4700. Epub 2024 Sep 17.
6
The impact of interleukin-6 (IL-6) and mesenchymal stem cell-derived IL-6 on neurological conditions.白细胞介素-6（IL-6）及间充质干细胞源性IL-6对神经系统疾病的影响。
Front Immunol. 2024 Jun 24;15:1400533. doi: 10.3389/fimmu.2024.1400533. eCollection 2024.
7
Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis.干扰素和B细胞特征为狼疮性肾炎的精准医学提供依据。
Kidney Int Rep. 2024 Mar 13;9(6):1817-1835. doi: 10.1016/j.ekir.2024.03.014. eCollection 2024 Jun.
8
The role of interleukin-10 receptor alpha (IL10Rα) in Mycobacterium avium subsp. paratuberculosis infection of a mammary epithelial cell line.白细胞介素-10受体α（IL10Rα）在副结核分枝杆菌感染乳腺上皮细胞系中的作用。
BMC Genom Data. 2024 Jun 12;25(1):58. doi: 10.1186/s12863-024-01234-w.
9
Key genes and immune infiltration in chronic spontaneous urticaria: a study of bioinformatics and systems biology.慢性自发性荨麻疹的关键基因和免疫浸润：生物信息学和系统生物学研究。
Front Immunol. 2023 Nov 15;14:1279139. doi: 10.3389/fimmu.2023.1279139. eCollection 2023.
10
Right Ventricular Subclinical Dysfunction in SLE Patients Correlates with Metabolomic Fingerprint and Organ Damage.系统性红斑狼疮患者右心室亚临床功能障碍与代谢组学特征及器官损伤相关。
Metabolites. 2023 Jun 22;13(7):781. doi: 10.3390/metabo13070781.
本文引用的文献
1
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells.树突状细胞通过Toll途径依赖性方式阻断CD4+CD25+ T细胞介导的抑制作用。
Science. 2003 Feb 14;299(5609):1033-6. doi: 10.1126/science.1078231. Epub 2003 Jan 16.
2
The paradigm of IL-6: from basic science to medicine.白细胞介素-6的范例：从基础科学到医学
Arthritis Res. 2002;4 Suppl 3(Suppl 3):S233-42. doi: 10.1186/ar565. Epub 2002 May 9.
3
Impairment of CD8+ T suppressor cell function in patients with active systemic lupus erythematosus.活动性系统性红斑狼疮患者CD8 + T抑制细胞功能受损。
J Immunol. 2001 May 15;166(10):6452-7. doi: 10.4049/jimmunol.166.10.6452.
4
Anti-dsDNA antibody up-regulates interleukin 6, but not cyclo-oxygenase, gene expression in glomerular mesangial cells: a marker of immune-mediated renal damage?抗双链DNA抗体上调肾小球系膜细胞中白细胞介素6的表达，但不上调环氧化酶的基因表达：免疫介导肾损伤的一个标志物？
Inflamm Res. 2001 Jan;50(1):12-8. doi: 10.1007/s000110050718.
5
Association of IL-6 gene alleles with systemic lupus erythematosus (SLE) and with elevated IL-6 expression.白细胞介素-6（IL-6）基因等位基因与系统性红斑狼疮（SLE）及IL-6表达升高的关联。
Genes Immun. 1999 Sep;1(1):45-52. doi: 10.1038/sj.gene.6363631.
6
Cytokine production, serum levels and disease activity in systemic lupus erythematosus.系统性红斑狼疮中的细胞因子产生、血清水平与疾病活动度
Clin Exp Rheumatol. 2000 Sep-Oct;18(5):565-70.
7
8
IL-6 is required for the development of Th1 cell-mediated murine colitis.白细胞介素-6是Th1细胞介导的小鼠结肠炎发展所必需的。
J Immunol. 2000 May 1;164(9):4878-82. doi: 10.4049/jimmunol.164.9.4878.
9
Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha from normal human mononuclear cells involving in the lupus pathogenesis.单克隆抗双链DNA自身抗体刺激正常人单核细胞表达和释放白细胞介素-1β、白细胞介素-6、白细胞介素-8、白细胞介素-10和肿瘤坏死因子-α，参与狼疮发病机制。
Immunology. 2000 Mar;99(3):352-60. doi: 10.1046/j.1365-2567.2000.00970.x.
Zotero 插件