去泛素化酶在癌症相关通路中的新兴作用。
Emerging roles of deubiquitinases in cancer-associated pathways.
机构信息
Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, L69 3BX, UK.
出版信息
IUBMB Life. 2010 Feb;62(2):140-57. doi: 10.1002/iub.300.
Abstract
Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c-Myc. Alternatively they can negatively regulate ubiquitin-dependent signalling cascades such as the NF-kappaB activation pathway. We review the current literature that associates DUBs with cancer and discuss their suitability as drug targets of the future.
摘要
去泛素化酶（DUBs）正在成为与癌症相关的许多途径的重要调节剂。它们可能调节关键癌基因的稳定性，USP28 稳定 c-Myc 就是一个例子。或者，它们可以负调控依赖泛素的信号级联反应，如 NF-κB 激活途径。我们综述了目前与癌症相关的 DUBs 的文献，并讨论了它们作为未来药物靶点的适用性。
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本文引用的文献
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The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway.泛素特异性蛋白酶 4（USP4）是 Wnt 信号通路中的一个新成员。
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CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.CYLD 通过使 HDAC6 失活并增加乙酰化微管蛋白的水平来负调控细胞周期进程。
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MdmX is a substrate for the deubiquitinating enzyme USP2a.X 女士是去泛素化酶 USP2a 的底物。
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NF-kappaB and cancer: how intimate is this relationship.NF-κB 与癌症：这种关系有多密切。
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The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.去泛素化酶BAP1通过与HCF-1相互作用来调节细胞生长。
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