Singh T D, Patial K, Vijayan V K, Ravi K
Department of Physiology, V P Chest Institute, University of Delhi, Delhi, India.
Indian J Chest Dis Allied Sci. 2009 Oct-Dec;51(4):217-24.
Even though oxidative stress has been proposed as an underlying mechanism for the symptoms in patients with obstructive sleep apnoea syndrome (OSAS), little information is available on the effects of anti-oxidant treatment on their improvement.
To observe the effects of anti-oxidant treatment on polysomnographic parameters and oxidative stress markers in OSAS patients.
Polysomnography (PSG) was performed on 20 male patients. They were administered continuous positive airway pressure (CPAP) therapy for two nights followed by oral intake of vitamin C (100 mg BD) [DOSAGE ERROR CORRECTED] and vitamin E (400 IU BD) for 45 days and a repeat PSG was done. Ten healthy normal subjects underwent the same protocol excepting the CPAP therapy.
In OSAS patients, plasma lipid peroxidation increased significantly and whole blood reduced glutathione decreased significantly. The CPAP therapy as well as anti-oxidant treatment reduced the lipid peroxidation and restored the reduced glutathione concentrations. After anti-oxidant intake, OSAS patients slept better with decrease in Epworth sleepiness score and the number of apnoeic episodes. They spent more time in stages 3 and 4 of sleep. The optimum pressure of CPAP device was significantly lowered also.
Oxidative stress contributes to sleep behaviour in OSAS patients, and anti-oxidant intake improves the quality of sleep in them.
尽管氧化应激被认为是阻塞性睡眠呼吸暂停综合征（OSAS）患者症状的潜在机制，但关于抗氧化治疗对其改善效果的信息却很少。
观察抗氧化治疗对OSAS患者多导睡眠图参数和氧化应激标志物的影响。
对20名男性患者进行多导睡眠图（PSG）检查。他们接受了两晚的持续气道正压通气（CPAP）治疗，随后口服维生素C（100毫克，每日两次）[剂量错误已纠正]和维生素E（400国际单位，每日两次），持续45天，之后再次进行PSG检查。10名健康正常受试者除不接受CPAP治疗外，接受相同方案。
在OSAS患者中，血浆脂质过氧化显著增加，全血还原型谷胱甘肽显著减少。CPAP治疗以及抗氧化治疗均降低了脂质过氧化并恢复了还原型谷胱甘肽浓度。摄入抗氧化剂后，OSAS患者睡眠质量改善，Epworth嗜睡评分和呼吸暂停发作次数减少。他们在睡眠3期和4期花费的时间更多。CPAP设备的最佳压力也显著降低。
氧化应激导致OSAS患者的睡眠行为异常，摄入抗氧化剂可改善他们的睡眠质量。
