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1
Associations between plasma osteopontin levels and the severities of coronary and aortic atherosclerosis.血浆骨桥蛋白水平与冠状动脉和主动脉粥样硬化严重程度之间的关联。
Atherosclerosis. 2010 Jun;210(2):668-70. doi: 10.1016/j.atherosclerosis.2009.12.024. Epub 2010 Jan 4.
2
The LDL-cholesterol to HDL-cholesterol ratio and the severity of coronary and aortic atherosclerosis.低密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比值以及冠状动脉和主动脉粥样硬化的严重程度。
Atherosclerosis. 2012 Jun;222(2):577-80. doi: 10.1016/j.atherosclerosis.2012.03.023. Epub 2012 Apr 2.
3
Associations between serum lipoprotein(a) levels and the severity of coronary and aortic atherosclerosis.血清脂蛋白(a)水平与冠状动脉和主动脉粥样硬化严重程度的相关性。
Atherosclerosis. 2012 May;222(1):241-4. doi: 10.1016/j.atherosclerosis.2012.02.008. Epub 2012 Feb 17.
4
In vivo magnetic resonance evaluation of associations between aortic atherosclerosis and both risk factors and coronary artery disease in patients referred for coronary angiography.对因冠状动脉造影而接受检查的患者，进行主动脉粥样硬化与危险因素及冠状动脉疾病之间关联的体内磁共振评估。
Am Heart J. 2004 Jul;148(1):137-43. doi: 10.1016/j.ahj.2004.03.008.
5
Multimodal cardiovascular magnetic resonance quantifies regional variation in vascular structure and function in patients with coronary artery disease: relationships with coronary disease severity.多模态心血管磁共振定量评估冠心病患者血管结构和功能的区域性变化：与冠状动脉疾病严重程度的关系。
J Cardiovasc Magn Reson. 2011 Oct 21;13(1):61. doi: 10.1186/1532-429X-13-61.
6
Osteopontin plasma levels and accelerated atherosclerosis in patients with CAD undergoing PCI: a prospective clinical study.接受经皮冠状动脉介入治疗的冠心病患者血浆骨桥蛋白水平与动脉粥样硬化加速：一项前瞻性临床研究
Coron Artery Dis. 2011 May;22(3):179-87. doi: 10.1097/MCA.0b013e3283441d0b.
7
Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis.血浆 C 反应蛋白水平与冠状动脉和主动脉粥样硬化严重程度的相关性。
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8
Plasma osteopontin as a predictor of coronary artery disease: association with echocardiographic characteristics of atherosclerosis.血浆骨桥蛋白作为冠心病的预测因子：与动脉粥样硬化的超声心动图特征的相关性。
J Clin Lab Anal. 2010;24(3):201-6. doi: 10.1002/jcla.20378.
9
Relation between low-density lipoprotein cholesterol and thoracic aortic atherosclerosis.低密度脂蛋白胆固醇与胸主动脉动脉粥样硬化之间的关系。
Am J Cardiol. 1999 Sep 1;84(5):603-5, A9. doi: 10.1016/s0002-9149(99)00389-6.
10
Aortic stiffness, impaired fasting glucose, and aging.主动脉僵硬度、空腹血糖受损与衰老。
Hypertension. 2010 Jan;55(1):18-20. doi: 10.1161/HYPERTENSIONAHA.109.135897. Epub 2009 Nov 23.

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Osteopontin as a Biomarker for Coronary Artery Disease.骨桥蛋白作为冠状动脉疾病的生物标志物
Cells. 2025 Jan 13;14(2):106. doi: 10.3390/cells14020106.
2
CXCL9, IL2RB, and SPP1, potential diagnostic biomarkers in the co-morbidity pattern of atherosclerosis and non-alcoholic steatohepatitis.趋化因子 (C-X-C 基元) 配体 9、白细胞介素 2 受体亚基 β 和分泌磷蛋白 1，动脉粥样硬化和非酒精性脂肪性肝炎合并症模式中的潜在诊断生物标志物。
Sci Rep. 2024 Jul 16;14(1):16364. doi: 10.1038/s41598-024-66287-4.
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Molecular Pathways of Vulnerable Carotid Plaques at Risk of Ischemic Stroke: A Narrative Review.易发生缺血性卒中的易损性颈动脉斑块的分子通路：一项叙述性综述
Int J Mol Sci. 2024 Apr 15;25(8):4351. doi: 10.3390/ijms25084351.
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Identification of key genes for atherosclerosis in different arterial beds.不同动脉床粥样硬化的关键基因鉴定。
Sci Rep. 2024 Mar 19;14(1):6543. doi: 10.1038/s41598-024-55575-8.
5
The Role of Osteopontin in Atherosclerosis and Its Clinical Manifestations (Atherosclerotic Cardiovascular Diseases)-A Narrative Review.骨桥蛋白在动脉粥样硬化及其临床表现（动脉粥样硬化性心血管疾病）中的作用——一项叙述性综述
Biomedicines. 2023 Nov 29;11(12):3178. doi: 10.3390/biomedicines11123178.
6
Levels of miR-130b-5p in peripheral blood are associated with severity of coronary artery disease.外周血 miR-130b-5p 水平与冠状动脉疾病严重程度相关。
Mol Biol Rep. 2021 Dec;48(12):7719-7732. doi: 10.1007/s11033-021-06780-5. Epub 2021 Oct 23.
7
Osteopontin and Transplantation: Where Are We Now?骨桥蛋白与移植：现状如何？
Arch Immunol Ther Exp (Warsz). 2021 May 21;69(1):15. doi: 10.1007/s00005-021-00617-6.
8
Osteopontin and osteoprotegerin in atherosclerotic plaque - are they significant markers of plaque vulnerability?骨桥蛋白和护骨素在动脉粥样硬化斑块中的作用——它们是斑块易损性的重要标志物吗？
Rom J Morphol Embryol. 2020 Jul-Sep;61(3):793-801. doi: 10.47162/RJME.61.3.17.
9
Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease.显性冠状动脉疾病患者血浆骨桥蛋白与精氨酸途径代谢物之间的关系
Front Physiol. 2020 Aug 6;11:982. doi: 10.3389/fphys.2020.00982. eCollection 2020.
10
Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia.人成纤维细胞、平滑肌细胞和内皮细胞的共培养促进缺氧诱导骨桥蛋白的表达。
J Cell Mol Med. 2020 Mar;24(5):2931-2941. doi: 10.1111/jcmm.14905. Epub 2020 Feb 7.

本文引用的文献

1
Association between osteopontin and human abdominal aortic aneurysm.骨桥蛋白与人类腹主动脉瘤之间的关联。
Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):655-60. doi: 10.1161/01.ATV.0000255560.49503.4e. Epub 2006 Dec 14.
2
Plasma osteopontin levels are elevated in non-ST-segment elevation acute coronary syndromes.非ST段抬高型急性冠状动脉综合征患者的血浆骨桥蛋白水平升高。
J Natl Med Assoc. 2006 Nov;98(11):1746-50.
3
Elevated plasma osteopontin levels were associated with osteopontin expression of CD4+ T cells in patients with unstable angina.不稳定型心绞痛患者血浆骨桥蛋白水平升高与CD4+T细胞的骨桥蛋白表达有关。
Circ J. 2006 Jul;70(7):851-6. doi: 10.1253/circj.70.851.
4
In vivo magnetic resonance evaluation of associations between aortic atherosclerosis and both risk factors and coronary artery disease in patients referred for coronary angiography.对因冠状动脉造影而接受检查的患者，进行主动脉粥样硬化与危险因素及冠状动脉疾病之间关联的体内磁共振评估。
Am Heart J. 2004 Jul;148(1):137-43. doi: 10.1016/j.ahj.2004.03.008.
5
Plasma osteopontin levels are associated with the presence and extent of coronary artery disease.血浆骨桥蛋白水平与冠状动脉疾病的存在及程度相关。
Atherosclerosis. 2003 Oct;170(2):333-7. doi: 10.1016/s0021-9150(03)00298-3.
6
Osteopontin transgenic mice fed a high-cholesterol diet develop early fatty-streak lesions.喂食高胆固醇饮食的骨桥蛋白转基因小鼠会早期出现脂肪条纹病变。
Circulation. 2003 Feb 11;107(5):679-81. doi: 10.1161/01.cir.0000055739.13639.d7.
7
Relation of coronary artery disease and cerebrovascular disease with atherosclerosis of the thoracic aorta in the general population.普通人群中冠状动脉疾病和脑血管疾病与胸主动脉动脉粥样硬化的关系。
Am J Cardiol. 2002 Feb 1;89(3):262-7. doi: 10.1016/s0002-9149(01)02225-1.
8
NK-104, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces osteopontin expression by rat aortic smooth muscle cells.NK-104，一种3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂，可降低大鼠主动脉平滑肌细胞的骨桥蛋白表达。
Br J Pharmacol. 2001 May;133(1):83-8. doi: 10.1038/sj.bjp.0704046.
9
Osteopontin is a constitutive component of normal elastic fibers in human skin and aorta.
Matrix Biol. 1995 Jul;14(7):553-60. doi: 10.1016/s0945-053x(05)80004-6.
10
Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques.骨桥蛋白在大鼠动脉新生内膜形成过程中升高，是人类动脉粥样硬化斑块的一种新成分。
J Clin Invest. 1993 Oct;92(4):1686-96. doi: 10.1172/JCI116755.

Associations between plasma osteopontin levels and the severities of coronary and aortic atherosclerosis.

作者信息

Momiyama Yukihiko, Ohmori Reiko, Fayad Zahi A, Kihara Teruyoshi, Tanaka Nobukiyo, Kato Ryuichi, Taniguchi Hiroaki, Nagata Masayoshi, Nakamura Haruo, Ohsuzu Fumitaka

出版信息

Atherosclerosis. 2010 Jun;210(2):668-70. doi: 10.1016/j.atherosclerosis.2009.12.024. Epub 2010 Jan 4.

DOI:10.1016/j.atherosclerosis.2009.12.024
PMID:20074733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3095031/
Abstract
摘要