载银纳米粒子的聚（乙烯醇）-b-聚（丙烯腈）基胶束的抗菌活性。
Antibacterial activity of poly(vinyl alcohol)-b-poly(acrylonitrile) based micelles loaded with silver nanoparticles.
机构信息
University of Chemical Technology and Metallurgy, Department Polymer Engineering, 8 Kl.Ohridski, 1756 Sofia, Bulgaria.
出版信息
J Colloid Interface Sci. 2010 Apr 15;344(2):424-8. doi: 10.1016/j.jcis.2009.12.040. Epub 2009 Dec 28.
A new amphiphilic poly(vinyl alcohol)-b-poly(acrylonitrile) (PVOH-b-PAN) copolymer obtained by selective hydrolysis of well-defined poly(vinyl acetate)-b-poly(acrylonitrile) copolymer synthesized by cobalt mediated radical polymerization was used for the preparation of PVOH-b-PAN based micelles with embedded silver nanoparticles. The successful formation of silver loaded micelles has been confirmed by UV-vis, DLS and TEM analysis and their antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa) and spore solution of Bacillus subtilis (B. subtilis) has been studied. PVOH-b-PAN based micelles with embedded silver nanoparticles showed a strong bactericidal effect against E. coli, S. aureus and P. aeruginosa and the minimum bactericidal concentration for each system (MBC) has been determined.
一种新型两亲性聚（聚乙烯醇）-b-聚（丙烯腈）（PVOH-b-PAN）嵌段共聚物，通过钴介导的自由基聚合合成的具有明确结构的聚（醋酸乙烯酯）-b-聚（丙烯腈）嵌段共聚物的选择性水解得到，用于制备负载银纳米粒子的 PVOH-b-PAN 基胶束。通过紫外-可见光谱、动态光散射和透射电子显微镜分析证实了银纳米粒子的成功负载，研究了其对大肠杆菌（E. coli）、金黄色葡萄球菌（S. aureus）、铜绿假单胞菌（P. aeruginosa）和枯草芽孢杆菌（B. subtilis）孢子溶液的抗菌活性。负载银纳米粒子的 PVOH-b-PAN 基胶束对大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌具有很强的杀菌作用，确定了每个体系的最小杀菌浓度（MBC）。
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