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未接受治疗的儿童强迫症的眶额皮质。

Orbital frontal cortex in treatment-naïve pediatric obsessive-compulsive disorder.

机构信息

Department of Psychiatry & Behavioral Neurosciences, Wayne State University, Children's Hospital of Michigan, Detroit, MI 48201, USA.

出版信息

Psychiatry Res. 2010 Feb 28;181(2):97-100. doi: 10.1016/j.pscychresns.2009.08.005. Epub 2010 Jan 13.

DOI:10.1016/j.pscychresns.2009.08.005
PMID:20074911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2830852/
Abstract

The orbital frontal cortex (OFC) has been implicated in obsessive-compulsive disorder (OCD). Participants comprised 28 treatment-naïve pediatric OCD patients and 21 controls, who were examined using magnetic resonance imaging. OCD patients had larger right but not left OFC white matter volume than controls. This is fresh evidence implicating white matter in OCD.

摘要

眶额皮层(OFC)与强迫症(OCD)有关。参与者包括 28 名未经治疗的儿科 OCD 患者和 21 名对照,他们接受了磁共振成像检查。OCD 患者的右侧眶额皮层(OFC)白质体积大于左侧,但左侧眶额皮层(OFC)白质体积大于对照组。这是一个新的证据表明,白质在 OCD 中起作用。

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本文引用的文献

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Glutamate system genes associated with ventral prefrontal and thalamic volume in pediatric obsessive-compulsive disorder.与儿童强迫症患者腹侧前额叶和丘脑体积相关的谷氨酸系统基因。
Brain Imaging Behav. 2009 Mar 1;3(1):64-76. doi: 10.1007/s11682-008-9050-3.
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Brain imaging in pediatric obsessive-compulsive disorder.小儿强迫症的脑成像
J Am Acad Child Adolesc Psychiatry. 2008 Nov;47(11):1262-72. doi: 10.1097/CHI.0b013e318185d2be.
3
White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives.
强迫障碍患者的自我防御风格与眶额皮质体积有关吗?
Psychiatry Investig. 2011 Jun;8(2):123-9. doi: 10.4306/pi.2011.8.2.123. Epub 2011 Feb 15.
强迫症患者及其一级亲属的白质异常。
Am J Psychiatry. 2008 Oct;165(10):1308-15. doi: 10.1176/appi.ajp.2008.07101677. Epub 2008 Jun 2.
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Developmental differences in white matter architecture between boys and girls.男孩与女孩之间白质结构的发育差异。
Hum Brain Mapp. 2008 Jun;29(6):696-710. doi: 10.1002/hbm.20431.
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A genetic family-based association study of OLIG2 in obsessive-compulsive disorder.一项基于遗传家族的强迫症中OLIG2基因关联研究。
Arch Gen Psychiatry. 2007 Feb;64(2):209-14. doi: 10.1001/archpsyc.64.2.209.
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The effects of temporary inactivation of the orbital cortex in the signal attenuation rat model of obsessive compulsive disorder.在强迫症信号衰减大鼠模型中眶皮质暂时失活的影响。
Behav Neurosci. 2006 Aug;120(4):976-83. doi: 10.1037/0735-7044.120.4.976.
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Volumetric MRI study of key brain regions implicated in obsessive-compulsive disorder.强迫症相关关键脑区的容积磁共振成像研究。
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):46-52. doi: 10.1016/j.pnpbp.2006.06.008. Epub 2006 Jul 20.
8
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