Laboratoire Physico-Chimie Curie, CNRS, Institut Curie, UPMC, 26 rue d'Ulm, F-75248 Paris Cedex 05, France.
Curr Opin Cell Biol. 2010 Feb;22(1):14-20. doi: 10.1016/j.ceb.2009.12.012. Epub 2010 Jan 13.
Many cellular processes require molecular motors to produce motion and forces. Single molecule experiments have led to a precise description of how a motor works. Under most physiological conditions, however, molecular motors operate in groups. Interactions between motors yield collective behaviors that cannot be explained only from single molecule properties. The aim of this paper is to review the various theoretical descriptions that explain the emergence of collective effects in molecular motor assemblies. These include bidirectional motion, hysteretic behavior, spontaneous oscillations, and self-organization into dynamical structures. We discuss motors acting on the cytoskeleton both in a prescribed geometry such as in muscles or flagella and in the cytoplasm.
许多细胞过程都需要分子马达来产生运动和力。单分子实验已经对马达的工作方式进行了精确描述。然而，在大多数生理条件下，分子马达是成群工作的。马达之间的相互作用产生了无法仅从单个分子特性来解释的集体行为。本文的目的是综述解释分子马达组装中集体效应出现的各种理论描述。这些描述包括双向运动、滞后行为、自发振荡和动态结构的自组织。我们讨论了在肌纤维或鞭毛等规定的几何形状以及细胞质中作用于细胞骨架的马达。
