Chen Q, Li D Y, Oiwa K
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada T6G 2V2.
Biophys Chem. 2007 Aug;129(1):60-9. doi: 10.1016/j.bpc.2007.05.008. Epub 2007 May 21.
Utilizing the mechanical energy converted from chemical energy through hydrolysis of ATP, motor proteins drive cytoskeleton filaments to move in various biological systems. Recent technological advance has shown the potential of the motor proteins for powering future nano-bio-mechanical systems. In order to effectively use motor proteins as a biological motor, the interaction between the protein motors and bio-filaments needs to be well clarified, since such interaction is largely influenced by many factors, such as the coordination among the motors, their dynamic behavior, physical properties of microtubules, and the viscosity of solution involved, etc. In this study, a two-dimensional model was proposed to simulate the motion of a microtubule driven by protein motors based on a dissipative particle dynamics (DPD) method with attempt to correlate the microtubule's kinetic behavior to the coordination among protein motors.
利用通过ATP水解将化学能转化而来的机械能，马达蛋白驱动细胞骨架细丝在各种生物系统中移动。最近的技术进步显示了马达蛋白为未来纳米生物机械系统提供动力的潜力。为了有效地将马达蛋白用作生物马达，需要充分阐明蛋白质马达与生物细丝之间的相互作用，因为这种相互作用在很大程度上受许多因素影响，如马达之间的协同作用、它们的动态行为、微管的物理性质以及所涉及溶液的粘度等。在本研究中，基于耗散粒子动力学（DPD）方法提出了一个二维模型，以模拟由蛋白质马达驱动的微管的运动，试图将微管的动力学行为与蛋白质马达之间的协同作用联系起来。
