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苯和非霍奇金淋巴瘤的风险:文献综述和荟萃分析。

Benzene and the risk of non-Hodgkin lymphoma: a review and meta-analysis of the literature.

机构信息

Epidemiology and Genetics Unit, Department of Health Sciences, Seebohm Rowntree Building, University of York, YO10 5DD, UK.

出版信息

Cancer Epidemiol. 2010 Feb;34(1):7-12. doi: 10.1016/j.canep.2009.12.011. Epub 2010 Jan 13.

Abstract

Benzene, an accepted leukemogen, has been suggested to cause other hemato- and lymphopoietic cancers. Here we review the published literature for non-Hodgkin lymphoma (NHL) and occupational exposure to benzene. Six cohorts, sixteen case-control studies and two studies of other designs were identified through keyword searches of bibliographic databases. Twenty-two of twenty-four studies found no association between NHL and ever exposed to benzene compared to never; a random-effects meta-analysis gave a pooled risk estimate of 1.11 (95% confidence interval 0.94-1.30). Our finding of no effect agrees with one of two previous meta-analyses. The other meta-analysis examined if high benzene exposure increased NHL risk but a lack of consistent exposure categories within the same metric should have precluded pooling risks by exposure level. Instead, we reviewed whether dose-response relationships existed. The best available data came from six studies where exposure was estimated from historical measurements and on the whole, no trends in risks of NHL with rising cumulative, average, peak, or duration of benzene exposure were found. NHL is a heterogeneous group of malignancies and although less well-studied, benzene was not associated with any NHL subtype. In conclusion, benzene at either low or high doses does not increase the risk of NHL.

摘要

苯是一种公认的白血病致癌物,据推测它还会导致其他血液和淋巴系统肿瘤。在这里,我们对苯致非霍奇金淋巴瘤(NHL)和职业暴露的已发表文献进行了综述。通过对文献数据库的关键词搜索,共确定了六个队列、十六项病例对照研究和两项其他设计的研究。与从不接触相比,二十四项研究中有二十二项研究未发现 NHL 与既往接触苯之间存在关联;一项随机效应荟萃分析得出的综合风险估计值为 1.11(95%置信区间为 0.94-1.30)。我们的无效应发现与之前的两项荟萃分析之一一致。另一项荟萃分析检查了高苯暴露是否会增加 NHL 风险,但由于同一指标内缺乏一致的暴露类别,因此不应按暴露水平对风险进行汇总。相反,我们审查了是否存在剂量-反应关系。来自六个研究的最佳可用数据表明,暴露是根据历史测量值估算的,总的来说,随着累积、平均、峰值或暴露时间的增加,NHL 的风险没有趋势。NHL 是一组异质性的恶性肿瘤,尽管研究较少,但苯与任何 NHL 亚型均无关联。总之,低剂量或高剂量的苯均不会增加 NHL 的风险。

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