Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Incheon, Korea.
Saf Health Work. 2011 Jun;2(2):135-47. doi: 10.5491/SHAW.2011.2.2.135. Epub 2011 Jun 30.
The purpose of this study was to evaluate cancer risks in the Korean semiconductor industry.
A retrospective cohort study was performed in eight semiconductor factories between 1998 and 2008. The number of subjects was 113,443 for mortality and 108,443 for incidence. Standardized mortality ratios (SMR) and standardized incidence ratios (SIR) were calculated.
The SMR of leukemia was 0.39 (95% Confidence Interval 0.08-1.14) in males (2 cases) and 1.37 (0.55-2.81) in females (7 cases). The SMR of non-Hodgkin's lymphoma (NHL) was 1.33 (0.43-3.09, 5 cases) in males and 2.5 (0.68-6.40, 4 cases) in females. The SIR of leukemia was 0.69 (0.30-1.37, 8 cases) in males and 1.28 (0.61-2.36, 10 cases) in females. The SIR of NHL in females was 2.31 (1.23-3.95, 13 cases) and that of thyroid cancer in males was 2.11 (1.49-2.89, 38 cases). The excess incidence of NHL was significant in female assembly operators [SIR=3.15 (1.02-7.36, 5 cases)], but not significant in fabrication workers. The SIR of NHL in the group working for 1-5 years was higher than the SIR of NHL for those working for more than five years. The excess incidence of male thyroid cancer was observed in both office and manufacturing workers.
There was no significant increase of leukemia in the Korean semiconductor industry. However, the incidence of NHL in females and thyroid cancer in males were significantly increased even though there was no definite association between work and those diseases in subgroup analysis according to work duration. This result should be interpreted cautiously, because the majority of the cohort was young and the number of cases was small.
本研究旨在评估韩国半导体行业的癌症风险。
对 1998 年至 2008 年间的八家半导体工厂进行了回顾性队列研究。死亡率的研究对象为 113443 人，发病率的研究对象为 108443 人。计算了标准化死亡率比（SMR）和标准化发病率比（SIR）。
男性（2 例）白血病 SMR 为 0.39（95%置信区间 0.08-1.14），女性（7 例）为 1.37（0.55-2.81）。男性非霍奇金淋巴瘤（NHL）SMR 为 1.33（0.43-3.09，5 例），女性为 2.5（0.68-6.40，4 例）。男性白血病 SIR 为 0.69（0.30-1.37，8 例），女性为 1.28（0.61-2.36，10 例）。女性 NHL 的 SIR 为 2.31（1.23-3.95，13 例），男性甲状腺癌的 SIR 为 2.11（1.49-2.89，38 例）。女性装配工 NHL 的发病率过高[发病率比（SIR）=3.15（1.02-7.36，5 例）]，但在制造工人中无显著差异。工作 1-5 年的 NHL 发生率高于工作 5 年以上的 NHL 发生率。男性甲状腺癌的发病率在办公室和制造业工人中均有升高。
韩国半导体行业白血病的发病率没有显著增加。然而，女性 NHL 和男性甲状腺癌的发病率显著增加，尽管根据工作年限进行亚组分析时，工作与这些疾病之间没有明确的关联。由于该队列的大多数人年龄较小，且病例数量较少，因此该结果应谨慎解释。
