苯暴露与非霍奇金淋巴瘤：流行病学研究的荟萃分析。
Benzene exposure and non-Hodgkin lymphoma: a meta-analysis of epidemiologic studies.
机构信息
Center for Epidemiology, Biostatistics, and Computational Biology, Exponent Inc., Health Sciences, Wood Dale, IL 60191, USA.
出版信息
J Occup Environ Med. 2010 Feb;52(2):169-89. doi: 10.1097/JOM.0b013e3181cc9cf0.
OBJECTIVE
To conduct a meta-analysis of studies of benzene exposure and non-Hodgkin lymphoma (NHL).
METHODS
A total of 8 cohort and 14 case-control studies were analyzed.
RESULTS
Meta-analysis of any benzene exposure resulted in a summary relative risk estimate (SRRE) of 1.02 (95% CI: 0.94 to 1.12). The SRRE changed minimally when only data representing the highest level of benzene exposure were analyzed after an a priori data extraction protocol, using cumulative exposure as the optimum metric (SRRE = 1.08, 95% CI: 0.93 to 1.24). Meta-analysis of five studies that reported results for 60 or more ppm-years of cumulative exposure yielded an SRRE of 1.08 (95% CI: 0.36 to 3.24). Similarly, an SRRE of 1.04 (95% CI: 0.96 to 1.12) for each 25 ppm-year increment of benzene exposure was observed.
CONCLUSIONS
The results from this meta-analysis are not supportive of an independent association between benzene exposure and NHL.
目的
对苯暴露与非霍奇金淋巴瘤（NHL）的研究进行荟萃分析。
方法
共分析了 8 项队列研究和 14 项病例对照研究。
结果
对任何苯暴露进行荟萃分析，得出的综合相对风险估计值（SRRE）为 1.02（95%CI：0.94 至 1.12）。根据事先制定的数据提取方案，仅分析代表最高苯暴露水平的数据后，SRRE 变化很小，使用累积暴露作为最佳指标（SRRE=1.08，95%CI：0.93 至 1.24）。对五项报告累积暴露 60 或更多 ppm 年的研究进行荟萃分析，得出的 SRRE 为 1.08（95%CI：0.36 至 3.24）。同样，观察到苯暴露每增加 25 ppm 年，SRRE 为 1.04（95%CI：0.96 至 1.12）。
结论
这项荟萃分析的结果不支持苯暴露与 NHL 之间存在独立关联。
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