Department of Epidemiology and Public Health, University College London, London, UK.
Obesity (Silver Spring). 2010 Oct;18(10):1981-7. doi: 10.1038/oby.2009.497. Epub 2010 Jan 14.
The aim of this study is to examine the association of BMI and waist circumference (WC), with a quality of life (QoL) indicator designed for older ages (CASP19), and with depressive symptoms (Centre for Epidemiologic Studies Depression Scale). We included 8,688 individuals aged ≥52 years who participants of Wave 2 (2004-2005) and Wave 3 (2006-2007) of the English Longitudinal Study of Ageing (ELSA). To explore cross-sectional relationships (2004-2005), we fitted regression models for BMI and WC (included simultaneously) as our predictors of QoL and depressive symptoms adjusted for covariates. To explore longitudinal relationships, BMI and waist at baseline (2004-2005) were related to the each outcome variable measured at follow-up (2006-2007), and adjusted for baseline characteristics (2004-2005). For a given BMI, larger WC was associated with lower QoL and higher risk of depressive symptoms for women in cross-sectional and longitudinal analyses. By contrast for a given WC increased BMI for women was positively associated with QoL and lower odds of depressive symptoms. In men, for a given BMI, increased WC was related to QoL only cross-sectionally; neither WC nor BMI at baseline were associated with depressive symptoms (cross-sectionally or longitudinally). In conclusion among older people, for a given BMI, increased WC was related with higher risk of poor QoL and, for women, of depressive symptoms; whereas for a given WC, increased BMI had a protective effect on QoL for women.
本研究旨在探讨体质指数（BMI）和腰围（WC）与专门针对老年人设计的生活质量（QoL）指标（CASP19）以及抑郁症状（流行病学研究抑郁量表）之间的关联。我们纳入了 8688 名年龄≥52 岁的个体，他们是英国老龄化纵向研究（ELSA）第 2 波（2004-2005 年）和第 3 波（2006-2007 年）的参与者。为了探索横断面关系（2004-2005 年），我们拟合了 BMI 和 WC（同时纳入）作为我们的预测因子的回归模型，这些预测因子调整了协变量后与 QoL 和抑郁症状相关。为了探索纵向关系，基线（2004-2005 年）的 BMI 和腰围与随访期间测量的每个结果变量（2006-2007 年）相关，并调整了基线特征（2004-2005 年）。对于给定的 BMI，较大的 WC 与女性在横断面和纵向分析中的 QoL 较低和抑郁症状风险较高相关。相比之下，对于给定的 WC，女性 BMI 的增加与 QoL 呈正相关，抑郁症状的可能性较低。在男性中，对于给定的 BMI，WC 的增加仅与横断面的 QoL 相关；基线时的 WC 或 BMI 均与抑郁症状（横断面或纵向）无关。总之，在老年人中，对于给定的 BMI，增加的 WC 与较差的 QoL 风险增加相关，对于女性而言，与抑郁症状相关；而对于给定的 WC，女性 BMI 的增加对 QoL 具有保护作用。
