啤酒中的挥发性和非挥发性亚硝胺。
Volatile and nonvolatile nitrosamines in beer.
作者信息
Tricker A R, Preussmann R
机构信息
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
出版信息
J Cancer Res Clin Oncol. 1991;117(2):130-2. doi: 10.1007/BF01613136.
Abstract
The occurrence of N-nitroso compounds was investigated at different stages in the production of four different beer types and in 14 retail beer samples. Only two N-nitroso compounds, namely N-nitrosodimethylamine (0.17 +/- 0.18 microgram/kg; not detected to 0.60 microgram/kg) and N-nitrosoproline (1.51 +/- 1.01 micrograms/kg; range 0.5-3.60 micrograms/kg) were detected. For moderate beer drinkers, the N-nitrosodimethylamine exposure levels are unlikely to present a significant health risk while the presence of noncarcinogenic N-nitrosoproline does not pose any hazard to human health.
摘要
对四种不同类型啤酒生产的不同阶段以及14个零售啤酒样品中的N-亚硝基化合物的存在情况进行了调查。仅检测到两种N-亚硝基化合物，即N-亚硝基二甲胺（0.17±0.18微克/千克；未检出至0.60微克/千克）和N-亚硝基脯氨酸（1.51±1.01微克/千克；范围为0.5 - 3.60微克/千克）。对于适度饮用啤酒的人来说，N-亚硝基二甲胺的暴露水平不太可能带来重大健康风险，而非致癌性的N-亚硝基脯氨酸的存在对人类健康不构成任何危害。
相似文献
1
Volatile and nonvolatile nitrosamines in beer.啤酒中的挥发性和非挥发性亚硝胺。
J Cancer Res Clin Oncol. 1991;117(2):130-2. doi: 10.1007/BF01613136.
2
Development and Validation of a Sensitive LC-MS/MS Method for Simultaneous Determination of Several Nitrosamines in Large Volume Parenteral.大容量注射剂中多种亚硝胺同时测定的灵敏液相色谱-串联质谱法的建立与验证
J AOAC Int. 2025 Jul 1;108(4):519-530. doi: 10.1093/jaoacint/qsaf031.
3
Occurrence in human urine of new sulphur-containing N-nitrosamino acids N-nitrosothiazolidine 4-carboxylic acid and its 2-methyl derivative, and their formation.新的含硫N-亚硝基氨基酸N-亚硝基噻唑烷-4-羧酸及其2-甲基衍生物在人尿中的出现及其形成。
J Cancer Res Clin Oncol. 1984;108(1):121-8. doi: 10.1007/BF00390983.
4
Foetal haemoglobin inducers for reducing blood transfusion in non-transfusion-dependent beta-thalassaemias.诱导胎儿血红蛋白生成以减少非输血依赖型β-地中海贫血的输血。
Cochrane Database Syst Rev. 2023 Jan 13;1(1):CD013767. doi: 10.1002/14651858.CD013767.pub2.
5
Contamination of toiletries and cosmetic products with volatile and nonvolatile N-nitroso carcinogens.洗漱用品和化妆品被挥发性和非挥发性N-亚硝基致癌物污染。
J Cancer Res Clin Oncol. 1984;108(1):160-3. doi: 10.1007/BF00390990.
6
Interventions for preventing weight gain after smoking cessation.戒烟后预防体重增加的干预措施。
Cochrane Database Syst Rev. 2012 Jan 18;1:CD006219. doi: 10.1002/14651858.CD006219.pub3.
7
Volatile N-nitrosamines in Polish malt and beer.
Food Addit Contam. 1989 Jan-Mar;6(1):29-33. doi: 10.1080/02652038909373736.
8
Enzyme replacement and substrate reduction therapy for Gaucher disease.戈谢病的酶替代疗法和底物减少疗法。
Cochrane Database Syst Rev. 2015 Mar 27;2015(3):CD010324. doi: 10.1002/14651858.CD010324.pub2.
9
Drugs for treating Schistosoma mansoni infection.用于治疗曼氏血吸虫感染的药物。
Cochrane Database Syst Rev. 2013 Feb 28;2013(2):CD000528. doi: 10.1002/14651858.CD000528.pub2.
10
Low-carbohydrate versus balanced-carbohydrate diets for reducing weight and cardiovascular risk.低碳水化合物饮食与均衡碳水化合物饮食在减轻体重和降低心血管风险方面的比较。
Cochrane Database Syst Rev. 2022 Jan 28;1(1):CD013334. doi: 10.1002/14651858.CD013334.pub2.
引用本文的文献
1
Risk assessment of nitrosamines in food.食品中亚硝胺的风险评估。
EFSA J. 2023 Mar 28;21(3):e07884. doi: 10.2903/j.efsa.2023.7884. eCollection 2023 Mar.
2
Alcohol drinking and gastric cancer risk: a meta-analysis of observational studies.饮酒与胃癌风险：观察性研究的荟萃分析
Oncotarget. 2017 Sep 15;8(58):99013-99023. doi: 10.18632/oncotarget.20918. eCollection 2017 Nov 17.
3
Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer.葡萄酒、啤酒、酒精与多酚对心血管疾病和癌症的影响。
Nutrients. 2012 Jul;4(7):759-781. doi: 10.3390/nu4070759. Epub 2012 Jul 10.
4
Development of estimates of dietary nitrates, nitrites, and nitrosamines for use with the Short Willet Food Frequency Questionnaire.开发用于短嘴鹬食物频率问卷的膳食硝酸盐、亚硝酸盐和亚硝胺估计值。
Nutr J. 2009 Apr 6;8:16. doi: 10.1186/1475-2891-8-16.
本文引用的文献
1
Volatile nitrosamines in food.
Oncology. 1980;37(4):211-6. doi: 10.1159/000225438.
2
Daily dietary intakes of nitrate, nitrite and volative N-nitrosamines in the Netherlands using the duplicate portion sampling technique.采用双份膳食样本采集技术对荷兰居民膳食中硝酸盐、亚硝酸盐和挥发性N-亚硝胺的每日摄入量进行的研究。
Oncology. 1980;37(4):203-10. doi: 10.1159/000225437.
3
N-nitrosodimethylamine in beer.
Food Cosmet Toxicol. 1980 Feb;18(1):27-9. doi: 10.1016/0015-6264(80)90006-1.
4
N-nitrosodimethylamine in domestic beer in China.
Food Chem Toxicol. 1982 Apr;20(2):213-4. doi: 10.1016/s0278-6915(82)80251-2.
5
Determination of volatile nitrosamine levels in foods and estimation of their daily intake in Japan.
Food Chem Toxicol. 1984 Jan;22(1):61-4. doi: 10.1016/0278-6915(84)90054-1.
6
Incidence of some non-volatile N-nitroso compounds in cured meats.
Food Addit Contam. 1984 Jul-Sep;1(3):245-52. doi: 10.1080/02652038409385851.
7
Isolation and characterization of products from the nitrosation of the alkaloid gramine.
Food Chem Toxicol. 1985 Sep;23(9):841-7. doi: 10.1016/0278-6915(85)90285-6.
8
N-nitrosamines in Chinese foods.中国食品中的N-亚硝胺。
Food Chem Toxicol. 1988 Mar;26(3):205-8. doi: 10.1016/0278-6915(88)90120-2.
9
Volatile nitrosamines in foods and beverages: preliminary survey of the Italian market.食品和饮料中的挥发性亚硝胺：意大利市场初步调查
Bull Environ Contam Toxicol. 1988 Jan;40(1):41-6. doi: 10.1007/BF01689384.
10
The occurrence of N-nitrosocompounds [corrected] in zarda tobacco.
Cancer Lett. 1988 Sep-Oct;42(1-2):113-8. doi: 10.1016/0304-3835(88)90247-9.
Zotero 插件