van der Steen P H, van Baar H M, Happle R, Boezeman J B, Perret C M
Department of Dermatology, University of Nijmegen, The Netherlands.
J Am Acad Dermatol. 1991 Feb;24(2 Pt 1):227-30. doi: 10.1016/0190-9622(91)70032-w.
One hundred thirty-nine patients with alopecia areata were treated with diphenylcyclopropenone. Before treatment, 85 patients had subtotal or total hair loss (greater than 90% bald area) and in the remaining patients scalp involvement was between 40% and 90%. The following three factors were found to be of prognostic significance: type of alopecia areata as documented before treatment, duration of the disease before therapy, and presence of nail changes. Other factors such as age at onset, sex, presence of atopic features, the extent of variation in the range of diphenylcyclopropenone concentrations during treatment, and sleep disturbances caused by pruritus did not influence the prognosis significantly.
139例斑秃患者接受了二苯环丙烯酮治疗。治疗前，85例患者有部分或全部脱发（秃发面积大于90%），其余患者头皮受累面积在40%至90%之间。发现以下三个因素具有预后意义：治疗前记录的斑秃类型、治疗前疾病持续时间以及指甲改变情况。其他因素，如发病年龄、性别、特应性特征的存在、治疗期间二苯环丙烯酮浓度范围的变化程度以及瘙痒引起的睡眠障碍，对预后没有显著影响。
