Eurometaux, Brussels, Belgium.
J Toxicol Environ Health A. 2010;73(2):101-7. doi: 10.1080/15287390903337076.
This review considers the development of the regulatory process for metals in the European Union (Regulation for Registration, Evaluation, Authorisation and Restriction of Chemicals, REACH). The manner in which the REACH process was developed, its history, and the relative involvement of government and industry are examined. The problems involved in setting up the system and the steps in optimisation are considered. One of the major difficulties in the development of the REACH mechanism was incorporating the fact that many metals are essential elements, which is not a factor that most toxicological examinations consider. How the REACH process evolved to deal with these problems and how the mechanisms were put in place to overcome them is examined. Looking specifically at examples of industry working with academia, one needs to consider how a risk assessment can be developed and submitted in a timely and successful fashion.
本综述探讨了欧盟金属监管程序的发展（化学品注册、评估、授权和限制法规，REACH）。审查了 REACH 程序的开发方式、历史以及政府和行业的相对参与情况。考虑了建立该系统的问题和优化步骤。REACH 机制开发过程中的主要困难之一是纳入许多金属是必需元素这一事实，而大多数毒理学检查并不考虑这一因素。审查了 REACH 流程如何发展以应对这些问题以及如何建立机制来克服这些问题。具体来看，行业与学术界合作的例子表明，人们需要考虑如何及时、成功地制定和提交风险评估。
