Sail Giyab A, Zuo Ke-jun, Xu Geng
Otorhinolaryngology Hospital and Institute of the First Affiliated Hospital of SUN Yat-sen University, Guangzhou, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Sep;44(9):739-45.
To observe the efficacy of nasal glucocorticoid continuously used for 12 weeks on nasal obstruction in patients with persistent non-allergic rhinitis (PNAR).
The changes of nasal obstruction, nasal resistance, nasal mucous membrane and quality of life in 47 patients with PNAR were observed. The efficacy of nasal glucocorticoid (Mometasone Furoate Nasal Spray, MFNS 200 microg/day) on patients with PNAR was evaluated.
The results of nasal glucocorticoid (MFNS) continuously used for 12 weeks demonstrated: (1) After treatment, the nasal obstruction, nasal discharge, nasal obstruction related dizziness, headache, hyposmia, daily life activity, whole body fatigue, mental status were significantly improved (P < 0.05). (2) Nasal resistance showed significant amelioration (pre-treatment = 0.28 +/- 0.10, post- treatment = 0.16 +/- 0.05; F = 91.471, P < 0.05). (3) SF-36 questionnaire revealed that role physical, bodily pain, general health, role emotional had significant amelioration (P < 0.01). (4) SNOT-20 questionnaire revealed that the defatigation, impaired concentration, pinch the nose, nasal discharging into the throat, sleep quality had significant amelioration (P < 0.01). (5) Continued treatment for 12 weeks was better than 4 weeks, continued treatment had good effect.
The study shows that nasal glucocorticoid improved the nasal obstruction, nasal resistance, nasal mucous membrane and quality of life in patients with PNAR.
观察持续使用12周鼻用糖皮质激素对持续性非变应性鼻炎（PNAR）患者鼻塞的疗效。
观察47例PNAR患者鼻塞、鼻阻力、鼻黏膜及生活质量的变化。评估鼻用糖皮质激素（糠酸莫米松鼻喷雾剂，MFNS，200μg/天）对PNAR患者的疗效。
持续使用12周鼻用糖皮质激素（MFNS）的结果显示：（1）治疗后，鼻塞、流涕、鼻塞相关的头晕、头痛、嗅觉减退、日常生活活动、全身疲劳、精神状态均有显著改善（P<0.05）。（2）鼻阻力显著改善（治疗前=0.28±0.10，治疗后=0.16±0.05；F=91.471，P<0.05）。（3）SF-36问卷显示，身体功能、身体疼痛、总体健康、情感功能有显著改善（P<0.01）。（4）SNOT-20问卷显示，疲劳、注意力不集中、捏鼻、鼻涕倒流至咽喉、睡眠质量有显著改善（P<0.01）。（5）持续治疗12周优于4周，持续治疗效果良好。
研究表明，鼻用糖皮质激素可改善PNAR患者的鼻塞、鼻阻力、鼻黏膜及生活质量。
