Department of Pharmacology, Acharya and B.M. Reddy College of Pharmacy, Bangalore 560090, Karnataka, India.
Food Chem Toxicol. 2010 Apr;48(4):1013-8. doi: 10.1016/j.fct.2010.01.011. Epub 2010 Jan 15.
This study investigated the protective effect of the hydro-alcoholic extract of roots of Rubia cordifolia Linn. (HARC) against ethylene glycol induced urolithiasis and its possible underlying mechanisms using male Wistar albino rats. Ethylene glycol feeding resulted in hyperoxaluria, hypocalciuria as well as increased renal excretion of phosphate. Supplementation with HARC significantly prevented change in urinary calcium, oxalate and phosphate excretion dose-dependently. The increased calcium and oxalate levels and number of calcium oxalate crystals deposits in the kidney tissue of calculogenic rats were significantly reverted by HARC treatment. The HARC supplementation also prevents the impairment of renal functions.
Indicate that the HARC can protect against ethylene glycol induced urolithiasis as it reduced and prevented the growth of urinary stones. Therefore, HARC is helpful to prevent the recurrence of the disease as it showed its effect on early stages of stone development. The mechanism underlying this effect is mediated possibly through an antioxidant, nephroprotection and its effect on the urinary concentration of stone-forming constituents and risk factors.
本研究采用雄性 Wistar 白化大鼠，探讨了茜草根水醇提取物（HARC）对乙二醇诱导的尿石症的保护作用及其可能的机制。乙二醇喂养导致高草酸尿、低钙尿以及肾脏磷酸盐排泄增加。HARC 的补充显著地阻止了尿钙、草酸和磷酸盐排泄的剂量依赖性变化。HARC 治疗还显著逆转了结石形成大鼠肾组织中钙和草酸水平的升高以及草酸钙晶体沉积的数量。HARC 的补充还可以防止肾功能的损害。结果表明，HARC 可以预防乙二醇诱导的尿石症，因为它减少和阻止了尿路结石的生长。因此，HARC 有助于预防疾病的复发，因为它在结石形成的早期阶段就显示出了其作用。这种作用的机制可能是通过抗氧化、肾保护以及对尿液中结石形成成分和危险因素的浓缩作用来介导的。
