Department of Pharmacology, Bombay College of Pharmacy, Kalina, Mumbai, India.
J Ethnopharmacol. 2010 Mar 24;128(2):462-6. doi: 10.1016/j.jep.2010.01.025. Epub 2010 Jan 18.
In Indian traditional system of medicine, Ficus religiosa (Family Moraceae) is prescribed for the treatment of diabetes mellitus. In the present study, the antidiabetic effect of aqueous extract of Ficus religiosa bark (FRAE) was investigated in normal, glucose-loaded hyperglycemic and streptozotocin (STZ)-induced diabetic rats.
Oral administration of FRAE at the doses of 25, 50 and 100mg/kg was studied in normal, glucose-loaded and STZ-diabetic rats.
The three doses caused significant reduction in blood glucose levels in all the models. The effect was more pronounced in 50 and 100mg/kg than 25mg/kg. FRAE also showed significant increase in serum insulin, body weight and glycogen content in liver and skeletal muscle of STZ-induced diabetic rats while there was significant reduction in the levels of serum triglyceride and total cholesterol. FRAE also showed significant antilipidperoxidative effect in the pancreas of STZ-induced diabetic rats. The antidiabetic effect of Ficus religiosa was compared with glibenclamide, a well-known hypoglycemic drug.
The results indicate that aqueous extract of Ficus religiosa bark possesses significant antidiabetic activity.
在印度传统医学体系中，菩提树（桑科榕属）被用于治疗糖尿病。本研究旨在探讨菩提树树皮水提物（FRAE）对正常、葡萄糖负荷性高血糖和链脲佐菌素（STZ）诱导的糖尿病大鼠的降血糖作用。
在正常、葡萄糖负荷和 STZ 糖尿病大鼠中，分别给予 FRAE 25、50 和 100mg/kg 的口服剂量进行研究。
这三个剂量在所有模型中均显著降低血糖水平。50mg/kg 和 100mg/kg 的效果比 25mg/kg 更为明显。FRAE 还显著增加了 STZ 诱导的糖尿病大鼠血清胰岛素、体重和肝、骨骼肌糖原含量，同时显著降低了血清甘油三酯和总胆固醇水平。FRAE 还在 STZ 诱导的糖尿病大鼠的胰腺中表现出显著的抗脂质过氧化作用。将菩提树的降血糖作用与已知的降血糖药物格列本脲进行了比较。
研究结果表明，菩提树树皮水提物具有显著的降血糖活性。
