Department of Allergy and Immunology, Walter Reed Army Medical Center, Washington, DC, USA.
Med Hypotheses. 2010 Jun;74(6):1075-80. doi: 10.1016/j.mehy.2009.12.030. Epub 2010 Jan 18.
Gastroesophageal reflux (GER) and asthma have been linked, but the true nature of this relationship is incompletely understood. Most of the literature examining this association has implicated GER as the factor contributing to asthma. GER has also been linked to conditions of the upper airway like sinusitis and obstructive sleep apnea (OSA), and once again, usually presumed to be the causative factor. While GER seems to be capable of exacerbating airway disease, mounting evidence suggests that airway obstruction is a risk factor for developing GER. This article examines the principles of physics that predict what should occur given the anatomy of the airway and the esophagus, and provides multiple examples of disease associations that appear to support the hypothesis that airway obstruction is a significant risk factor for development of gastroesophageal reflux.
胃食管反流（GER）和哮喘之间存在关联，但这种关系的本质尚不完全清楚。大多数研究这种关联的文献都认为 GER 是导致哮喘的因素。GER 也与上呼吸道疾病如鼻窦炎和阻塞性睡眠呼吸暂停（OSA）有关，而且通常也被认为是致病因素。虽然 GER 似乎能够使气道疾病恶化，但越来越多的证据表明，气道阻塞是 GER 发展的危险因素。本文研究了物理学原理，根据气道和食管的解剖结构预测可能发生的情况，并提供了多个疾病关联的例子，这些例子似乎支持了气道阻塞是 GER 发展的重要危险因素的假说。
