Quek Chai-Hoon, Leong Kam W
Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Nanomaterials (Basel). 2012 Mar 30;2(2):92-112. doi: 10.3390/nano2020092.
Near-infrared (NIR) fluorescent probes offer advantages of high photon penetration, reduced light scattering and minimal autofluorescence from living tissues, rendering them valuable for noninvasive mapping of molecular events, assessment of therapeutic efficacy, and monitoring of disease progression in animal models. This review provides an overview of the recent development of the design and optical property of the different classes of NIR fluorescent nanoprobes associated with in vivo imaging applications.
近红外（NIR）荧光探针具有光子穿透性高、光散射减少以及活体组织自发荧光最小等优点，使其在分子事件的无创成像、治疗效果评估以及动物模型疾病进展监测方面具有重要价值。本文综述了与体内成像应用相关的不同类型近红外荧光纳米探针的设计和光学性质的最新进展。
